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GENETIC DIVERSITY OF MYCOBACTERIUM TUBERCULOSIS IN NORTHERN GREECE
Aristotle Univ Thessaloniki, Greece.
Autonomous Univ Barcelona, Spain.
Aristotle Univ Thessaloniki, Greece.
Sotiria Chest Dis Hosp, Greece; Sotiria Chest Dis Hosp, Greece.
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2018 (English)In: Journal of Biological Regulators and Homeostatic Agents, ISSN 0393-974X, E-ISSN 1724-6083, Vol. 32, no 4, p. 931-936Article in journal (Refereed) Published
Abstract [en]

The aim of the present study was to describe the genetic diversity of Mycobacterium tuberculosis (M.tuberculosis) strains circulating in the region of Northern Greece. A total of thirty-seven M. tuberculosis clinical isolates were analysed by the spoligotyping method. According to the results, six clusters comprising seventeen strains were detected, and the remaining twenty strains showed unique patterns. The M.tuberculosis families according to SITVITWEB were distributed as follows: Haarlem (H) (27.0%); T (24.3%); Beijing (13.5%); Latin-America and Mediterranean (LAM) (5.4%) and S (2.7%). The remaining isolates (27%) did not match any isolates within the database and they were characterized as orphans. Regarding GenoType MTBDRpIus results, two strains (5.4%) were Multi-Drug-Resistant, four strains (10.8%), were isoniazid monoresistant, while the remaining thirty-one strains (83.8%) were susceptible. In conclusion, in the region of Macedonia-Thrace (Northern Greece), there was high phylogenetic diversity among M. tuberculosis isolates. Molecular tools used and data presented can have regional and national impact on tuberculosis control.

Place, publisher, year, edition, pages
BIOLIFE SAS , 2018. Vol. 32, no 4, p. 931-936
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
URN: urn:nbn:se:liu:diva-152838ISI: 000449211500023OAI: oai:DiVA.org:liu-152838DiVA, id: diva2:1265140
Note

Funding Agencies|Miguel Servet

Available from: 2018-11-22 Created: 2018-11-22 Last updated: 2018-11-30Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
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