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Low Diversity of Human Milk Oligosaccharides is Associated with Necrotising Enterocolitis in Extremely Low Birth Weight Infants
Linköping University, Department of Clinical and Experimental Medicine, Division of Children's and Women's health. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center of Paediatrics and Gynaecology and Obstetrics, Department of Paediatrics in Norrköping.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences.ORCID iD: 0000-0002-1927-4656
Karolinska Univ Hosp, Sweden; Karolinska Inst, Sweden.
Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Medicine and Health Sciences.
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2018 (English)In: Nutrients, ISSN 2072-6643, E-ISSN 2072-6643, Vol. 10, no 10, article id 1556Article in journal (Refereed) Published
Abstract [en]

Difference in human milk oligosaccharides (HMO) composition in breast milk may be one explanation why some preterm infants develop necrotizing enterocolitis (NEC) despite being fed exclusively with breast milk. The aim of this study was to measure the concentration of 15 dominant HMOs in breast milk during the neonatal period and investigate how their levels correlated to NEC, sepsis, and growth in extremely low birth weight (ELBW; amp;lt;1000 g) infants who were exclusively fed with breast milk. Milk was collected from 91 mothers to 106 infants at 14 and 28 days and at postmenstrual week 36. The HMOs were analysed with high-performance anion-exchange chromatography with pulsed amperometric detection. The HMOs diversity and the levels of Lacto-N-difucohexaose I were lower in samples from mothers to NEC cases, as compared to non-NEC cases at all sampling time points. Lacto-N-difucohexaose I is only produced by secretor and Lewis positive mothers. There were also significant but inconsistent associations between 3-sialyllactose and 6-sialyllactose and culture-proven sepsis and significant, but weak correlations between several HMOs and growth rate. Our results suggest that the variation in HMO composition in breast milk may be an important factor explaining why exclusively breast milk fed ELBW infants develop NEC.

Place, publisher, year, edition, pages
MDPI , 2018. Vol. 10, no 10, article id 1556
Keywords [en]
neonatal; preterm; breast milk; oligosaccharides; diversity; necrotizing enterocolitis; sepsis; growth
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Pediatrics
Identifiers
URN: urn:nbn:se:liu:diva-152831DOI: 10.3390/nu10101556ISI: 000448821300222PubMedID: 30347801OAI: oai:DiVA.org:liu-152831DiVA, id: diva2:1265222
Note

Funding Agencies|Swedish Research Council [921.2014-7060]; Swedish Society for Medical Research; Swedish Society of Medicine; Research Council for the South-East Sweden; ALF Grants, Region Ostergotland; Ekhaga Foundation; BioGaia AB, Stockholm, Sweden

Available from: 2018-11-22 Created: 2018-11-22 Last updated: 2019-05-01

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Wejryd, ErikGeneró, Magali Marti

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Wejryd, ErikGeneró, Magali MartiWerme, AnnaLandberg, EvaAbrahamsson, Thomas
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Division of Children's and Women's healthFaculty of Medicine and Health SciencesDepartment of Paediatrics in NorrköpingDivision of Neuro and Inflammation ScienceDepartment of Clinical and Experimental MedicineDivision of Cell BiologyDepartment of Clinical ChemistryH.K.H. Kronprinsessan Victorias barn- och ungdomssjukhus
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