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Oral microbiota maturation during the first 7 years of life in relation to allergy development
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. CSIC, Spain; FISABIO, Spain; CIBER ESP, Spain.
Linköping University, Department of Clinical and Experimental Medicine, Division of Children's and Women's health. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center of Paediatrics and Gynaecology and Obstetrics, H.K.H. Kronprinsessan Victorias barn- och ungdomssjukhus.
FISABIO, Spain; CIBER ESP, Spain.
CSIC, Spain.
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2018 (English)In: Allergy. European Journal of Allergy and Clinical Immunology, ISSN 0105-4538, E-ISSN 1398-9995, Vol. 73, no 10, p. 2000-2011Article in journal (Refereed) Published
Abstract [en]

Background Allergic diseases have become a major public health problem in affluent societies. Microbial colonization early in life seems to be critical for instructing regulation on immune system maturation and allergy development in children. Even though the oral cavity is the first site of encounter between a majority of foreign antigens and the immune system, the influence of oral bacteria on allergy development has not yet been reported. Objective Methods We sought to determine the bacterial composition in longitudinally collected saliva samples during childhood in relation to allergy development. Illumina sequencing of the 16S rDNA gene was used to characterize the oral bacterial composition in saliva samples collected at 3, 6, 12, 24 months, and 7 years of age from children developing allergic symptoms and sensitization (n = 47) and children staying healthy (n = 33) up to 7 years of age. Results Conclusion Children developing allergic disease, particularly asthma, had lower diversity of salivary bacteria together with highly divergent bacterial composition at 7 years of age, showing a clearly altered oral microbiota in these individuals, likely as a consequence of an impaired immune system during infancy. Moreover, the relative amounts of several bacterial species, including increased abundance of Gemella haemolysans in children developing allergies and Lactobacillus gasseri and L. crispatus in healthy children, were distinctive during early infancy, likely influencing early immune maturation. Early changes in oral microbial composition seem to influence immune maturation and allergy development. Future experiments should test the probiotic potential of L. gasseri and L. crispatus isolates.

Place, publisher, year, edition, pages
WILEY , 2018. Vol. 73, no 10, p. 2000-2011
Keywords [en]
allergy development; Gemella haemolysans; infancy; Lactobacillus; oral microbiota
National Category
Pediatrics
Identifiers
URN: urn:nbn:se:liu:diva-152823DOI: 10.1111/all.13449ISI: 000449523600009PubMedID: 29602225OAI: oai:DiVA.org:liu-152823DiVA, id: diva2:1265235
Note

Funding Agencies|Spanish Ministry of Economy and Competitiveness [BIO2015-68711-R]; Swedish Research Council [2016-01698]; Swedish Heart and Lung Foundation [20140321]; Medical Research Council of Southeast Sweden [FORSS-573471]; Cancer and Allergy Foundation; European Research Council (ERC-starting grant) [639226]

Available from: 2018-11-22 Created: 2018-11-22 Last updated: 2019-04-18

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Dzidic, MajdaAbrahamsson, ThomasJenmalm, Maria
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Division of Neuro and Inflammation ScienceFaculty of Medicine and Health SciencesDivision of Children's and Women's healthH.K.H. Kronprinsessan Victorias barn- och ungdomssjukhus
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