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Quantifying the optical properties and chromophore concentrations of turbid media using polarization sensitive hyperspectral imaging: optical phantom studies
Spectral Molecular Imaging Inc., USA.
Beckman Laser Institute and Medical Clinic, USA.
Beckman Laser Institute and Medical Clinic, USA.
Spectral Molecular Imaging Inc., USA.
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2013 (English)In: Proceedings Volume 8587, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XI; 85870Z (2013) SPIE BiOS, 2013, San Francisco, California, United States / [ed] aniel L. Farkas, Dan V. Nicolau, and Robert C. Leif, SPIE - International Society for Optical Engineering, 2013, Vol. 8587, article id 85870ZConference paper, Published paper (Refereed)
Abstract [en]

We present a polarization-sensitive hyperspectral imaging system (SkinSpect) that employs a spectrally-programmable light source in the visible and NIR domains. Multiple tissue-mimicking phantoms were fabricated to mimic the optical properties of normal skin as well as pigmented light and dark moles. The phantoms consist of titanium dioxide and a mixture of coffee, red food dye, and naphthol green as the scattering and the three absorptive agents in a polydimethylsiloxane (PDMS) base. Phantoms were produced with both smooth and rough textured surfaces and tested using Spatial Frequency Domain Imaging (SFDI) and Spatially Modulated Quantitative Spectroscopy (SMoQS) for homogeneity as well as determining absorption and scattering variance, respectively. The reflectance spectral images were also recorded using the SkinSpect research prototype; the spectral signatures of the phantoms were calculated using a two-flux single-layer Kubelka-Munk model and non-negative least square fitting routine was applied to extract the relative concentrations of the individual phantom components.

Place, publisher, year, edition, pages
SPIE - International Society for Optical Engineering, 2013. Vol. 8587, article id 85870Z
National Category
Physical Sciences
Identifiers
URN: urn:nbn:se:liu:diva-152327DOI: 10.1117/12.2005371OAI: oai:DiVA.org:liu-152327DiVA, id: diva2:1265319
Conference
SPIE BIOS 2-7 February 2013 San Francisco, California, United States
Available from: 2018-11-22 Created: 2018-11-22 Last updated: 2018-12-03Bibliographically approved

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Saager, Rolf B.

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CiteExportLink to record
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Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
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Language
  • de-DE
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Output format
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