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Quantitative long term measurements of burns in a rat model using spatial frequency domain imaging and laser speckle imaging (Conference Presentation)
Beckman Laser Institute and Medical Clinic, USA.
Beckman Laser Institute and Medical Clinic, USA.
Beckman Laser Institute and Medical Clinic, USA.
Beckman Laser Institute and Medical Clinic, USA.
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2016 (English)In: Proceedings Volume 9711, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues IX; 971102 (2016) / [ed] Daniel L. Farkas, Dan V. Nicolau, and Robert C. Leif, SPIE - International Society for Optical Engineering, 2016, Vol. 9711, article id 971102Conference paper, Published paper (Refereed)
Abstract [en]

The ability to accurately assess burn wound severity in a timely manner is a critical component of wound management as it dictates the course of treatment. While full thickness and superficial burns can be easily diagnosed through visual inspection, burns that fall in between these categories are difficult to classify. Additionally, the ability to better quantify different stages of wound healing from a burn of any severity would be important for evaluating the efficacy of different treatment options. Here we present a longitudinal (28 day) study that employs spatial frequency domain imaging (SFDI) and laser speckle imaging (LSI) as non-invasive technologies to characterize in-vivo burn wounds and healing in a murine model. Burn wounds were created using an established technique of a brass comb heated to a given temperature and applied for a set amount of time. They were imaged immediately after the initial injury and then at 2, 4, 7, 14, 21, and 28 days following the injury. Biopsies were taken on the day of the injury in order to verify the extent of the burn damage as well as at different time points after the injury in order to visualize different stages of inflammation and healing. The results of this study suggest that the reduced scattering coefficient measured using SFDI and blood flow as measured using LSI have the potential to provide useful metrics for quantifying the severity of burn injuries as well as track the different stages associated with wound healing progression.

Place, publisher, year, edition, pages
SPIE - International Society for Optical Engineering, 2016. Vol. 9711, article id 971102
National Category
Physical Sciences
Identifiers
URN: urn:nbn:se:liu:diva-152316DOI: 10.1117/12.2214080OAI: oai:DiVA.org:liu-152316DiVA, id: diva2:1265506
Conference
SPIE BIOS, 13-18 February 2016, San Francisco, California, United States
Available from: 2018-11-23 Created: 2018-11-23 Last updated: 2018-11-23Bibliographically approved

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Saager, Rolf B.

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  • apa
  • harvard1
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