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In vivo isolation of the effects of melanin from underlying hemodynamics across skin types using spatial frequency domain spectroscopy
University of California, Irvine, USA.
University of California, Irvine, USA.
Beckman Laser Institute and Medical Clinic, USA.
University of California, Irvine, USA.
2016 (English)In: Journal of Biomedical Optics, ISSN 1083-3668, E-ISSN 1560-2281, Vol. 21, no 5, article id 057001Article in journal (Refereed) Published
Abstract [en]

Skin is a highly structured tissue, raising concerns as to whether skin pigmentation due to epidermal melanin may confound accurate measurements of underlying hemodynamics. Using both venous and arterial cuff occlusions as a means of inducing differential hemodynamic perturbations, we present analyses of spectra limited to the visible or near-infrared regime, in addition to a layered model approach. The influence of melanin, spanning Fitzpatrick skin types I to V, on underlying estimations of hemodynamics in skin as interpreted by these spectral regions are assessed. The layered model provides minimal cross-talk between melanin and hemodynamics and enables removal of problematic correlations between measured tissue oxygenation estimates and skin phototype.

Place, publisher, year, edition, pages
SPIE - International Society for Optical Engineering, 2016. Vol. 21, no 5, article id 057001
National Category
Biophysics
Identifiers
URN: urn:nbn:se:liu:diva-152312DOI: 10.1117/1.jbo.21.5.057001OAI: oai:DiVA.org:liu-152312DiVA, id: diva2:1265512
Available from: 2018-11-23 Created: 2018-11-23 Last updated: 2019-03-22

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Saager, Rolf B.

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CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf