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Multimode optical dermoscopy (SkinSpect) analysis for skin with melanocytic nevus
Spectral Molecular Imaging, Inc., USA.
Spectral Molecular Imaging, Inc., USA.
Beckman Laser Institute and Medical Clinic, Univ. of California, Irvine, USA.
Beckman Laser Institute and Medical Clinic, Univ. of California, Irvine, USA.
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2016 (English)In: Proceedings Volume 9711, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues IX; 971110 (2016) / [ed] Daniel L. Farkas, Dan V. Nicolau, and Robert C. Leif, SPIE - International Society for Optical Engineering, 2016, Vol. 8711, article id 971110Conference paper, Published paper (Refereed)
Abstract [en]

We have developed a multimode dermoscope (SkinSpect™) capable of illuminating human skin samples in-vivo with spectrally-programmable linearly-polarized light at 33 wavelengths between 468nm and 857 nm. Diffusely reflected photons are separated into collinear and cross-polarized image paths and images captured for each illumination wavelength. In vivo human skin nevi (N = 20) were evaluated with the multimode dermoscope and melanin and hemoglobin concentrations were compared with Spatially Modulated Quantitative Spectroscopy (SMoQS) measurements. Both systems show low correlation between their melanin and hemoglobin concentrations, demonstrating the ability of the SkinSpect™ to separate these molecular signatures and thus act as a biologically plausible device capable of early onset melanoma detection.

Place, publisher, year, edition, pages
SPIE - International Society for Optical Engineering, 2016. Vol. 8711, article id 971110
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Physical Sciences
Identifiers
URN: urn:nbn:se:liu:diva-152313DOI: 10.1117/12.2214288OAI: oai:DiVA.org:liu-152313DiVA, id: diva2:1265909
Conference
SPIE BIOS, 13-18 February 2016, San Francisco, California, United States
Available from: 2018-11-26 Created: 2018-11-26 Last updated: 2018-11-26Bibliographically approved

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Saager, Rolf B.

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