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Solid tissue simulating phantoms having absorption at 970 nm for diffuse optics
Beckman Laser Institute and Medical Clinic, USA.
Beckman Laser Institute and Medical Clinic, USA.
Beckman Laser Institute and Medical Clinic, USA.
Beckman Laser Institute and Medical Clinic, USA.
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2017 (English)In: Journal of Biomedical Optics, ISSN 1083-3668, E-ISSN 1560-2281, Vol. 22, no 7, article id 076013Article in journal (Refereed) Published
Abstract [en]

Tissue simulating phantoms can provide a valuable platform for quantitative evaluation of the performance of diffuse optical devices. While solid phantoms have been developed for applications related to characterizing exogenous fluorescence and intrinsic chromophores such as hemoglobin and melanin, we report the development of a poly(dimethylsiloxane) (PDMS) tissue phantom that mimics the spectral characteristics of tissue water. We have developed these phantoms to mimic different water fractions in tissue, with the purpose of testing new devices within the context of clinical applications such as burn wound triage. Compared to liquid phantoms, cured PDMS phantoms are easier to transport and use and have a longer usable life than gelatin-based phantoms. As silicone is hydrophobic, 9606 dye was used to mimic the optical absorption feature of water in the vicinity of 970 nm. Scattering properties are determined by adding titanium dioxide, which yields a wavelength-dependent scattering coefficient similar to that observed in tissue in the near-infrared. Phantom properties were characterized and validated using the techniques of inverse adding-doubling and spatial frequency domain imaging. Results presented here demonstrate that we can fabricate solid phantoms that can be used to simulate different water fractions.

Place, publisher, year, edition, pages
SPIE - International Society for Optical Engineering, 2017. Vol. 22, no 7, article id 076013
National Category
Physical Sciences
Identifiers
URN: urn:nbn:se:liu:diva-152305DOI: 10.1117/1.jbo.22.7.076013OAI: oai:DiVA.org:liu-152305DiVA, id: diva2:1265919
Available from: 2018-11-26 Created: 2018-11-26 Last updated: 2018-11-26Bibliographically approved

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