PINCH expression and its significance in esophageal squamous cell carcinoma
2008 (English)In: Disease Markers, ISSN 0278-0240, Vol. 25, no 2, 75-80 p.Article in journal (Refereed) Published
Particularly interesting new cysteine-histidine rich protein (PINCH), as a newly discovered protein of LIM family members, may play a role in signal transduction of integrin and growth factor, and involved in the incidence and development of tumors. PINCH protein is overexpressed in tumor-associated stroma of several types of tumors. However, there is no study of the PINCH in esophageal cancer, therefore we investigated PINCH expression in esophageal squamous cell carcinomas and its clinicopathogical significance in the patients. PINCH expression was immunohistochemically examined in 20 normal esophageal samples and 64 esophageal squamous cell carcinomas. The results showed that PINCH expression in the stroma of cancers was heterogeneous, and its positive rate (56%) was higher than that of normal esophageal mucosa (5%, p<0.0001). The stronger staining was observed at the invasive edge of tumor when compared to the inner area of tumor. The rate of positive PINCH (90%) in the cases with lymph node metastasis was higher than that (41%) in the cases without metastasis (p<0.0001). PINCH expression was not correlated with patients’ gender, age, tumor location, size and differentiation (p>0.05). The results suggest that PINCH protein may be a marker of tumor associated-stroma involving tumor development, and predicting the ability of invasion and metastasis of esophageal squamous cell carcinoma.
Place, publisher, year, edition, pages
2008. Vol. 25, no 2, 75-80 p.
PINCH, esophageal squamous cell carcinoma, immunohistochemistry
National CategoryMedical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-15598DOI: 10.1155/2008/473860OAI: oai:DiVA.org:liu-15598DiVA: diva2:126714
Original publication: Zhenlong Zhu, Yanhong Yang, Yu Zhang, Zhengmin Wang, Dongsheng Cui, Jinting Zhang, Mingwei Wang and Xiao-Feng Sun, PINCH expression and its significance in esophageal squamous cell carcinoma, 2008, Disease Markers, (25), 2, 75-80.http://iospress.metapress.com/content/j38j327k266413x5/. Copyright: IOS Press., http://iospress.metapress.com/2008-11-202008-11-202014-08-08Bibliographically approved