liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
A Preliminary Study of a Lettuce-Based Edible Vaccine Expressing the Cysteine Proteinase of Fasciola hepatica for Fasciolosis Control in Livestock
Polish Acad Sci, Poland.
Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences. Polish Acad Sci, Poland.
Polish Acad Sci, Poland.
Polish Acad Sci, Poland.
Show others and affiliations
2018 (English)In: Frontiers in Immunology, ISSN 1664-3224, E-ISSN 1664-3224, Vol. 9, article id 2592Article in journal (Refereed) Published
Abstract [en]

Oral vaccination with edible vaccines is one of the most promising approaches in modern vaccinology. Edible vaccines are an alternative to conventional vaccines, which are typically delivered by injection. Here, freeze-dried transgenic lettuce expressing the cysteine proteinase of the trematode Fasciola hepatica (CPFhVV) was used to orally vaccinate cattle and sheep against fasciolosis, which is the most important trematode disease due to the parasites global distribution, wide spectrum of host species and significant economic losses of farmers. In the study, goals such as reducing the intensity of infection, liver damage and F. hepatica fecundity were achieved. Moreover, we demonstrated that the host sex influenced the outcome of infection following vaccination, with female calves and male lambs showing better protection than their counterparts. Since differences occurred following vaccination and infection, different immunization strategies should be considered for different sexes and host species when developing new control methods. The results of the present study highlight the potential of oral vaccination with plant-made and plant-delivered vaccines for F. hepatica infection control.

Place, publisher, year, edition, pages
FRONTIERS MEDIA SA , 2018. Vol. 9, article id 2592
Keywords [en]
lettuce-derived vaccine; oral delivery; Fasciola hepatica; ruminants; cysteine protease
National Category
Microbiology in the medical area
Identifiers
URN: urn:nbn:se:liu:diva-153166DOI: 10.3389/fimmu.2018.02592ISI: 000450023200001OAI: oai:DiVA.org:liu-153166DiVA, id: diva2:1267323
Note

Funding Agencies|Polish Ministry of Scientific Research and Information Technology [PBZ-MIN-007/PO4]

Available from: 2018-12-01 Created: 2018-12-01 Last updated: 2019-03-22

Open Access in DiVA

fulltext(1424 kB)49 downloads
File information
File name FULLTEXT01.pdfFile size 1424 kBChecksum SHA-512
c719c7db968e2716357c744a384f8de38b4db0ddcf34b88d1a65e730ab34122f27bf8b58fdda3729c11de21f97b178cead51ebd9c43c44a6baa7f2b14542f0ec
Type fulltextMimetype application/pdf

Other links

Publisher's full text

Search in DiVA

By author/editor
Kozak Ljunggren, Monika
By organisation
Division of Cell BiologyFaculty of Medicine and Health Sciences
In the same journal
Frontiers in Immunology
Microbiology in the medical area

Search outside of DiVA

GoogleGoogle Scholar
Total: 49 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 49 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf