Symptoms in peri- and postmenopausal women in relation to testosterone concentrations. Data fromThe Women's Health in the Lund Area (WHILA) study
2008 (English)In: Climacteric, ISSN 1369-7137, Vol. 11, no 4, 304-314 p.Article in journal (Refereed) Published
Objectives: The aim of this study was to investigate possible associations between androgen concentrations in perimenopausal women and symptoms that may be associated with low androgen concentrations in the blood.
Methods: All women born 1935 to 1945 living in a defined geographic area in Sweden (n=10766) were invited to a screening program that included physical and laboratory examinations and a questionnaire. Three groups were identified; premenopausal women, women on hormone replacement therapy (HRT) and postmenopausal women without HRT. Concentrations of testosterone (T), androstendione, Sex Hormone Binding Globulin and estradiol were measured. Waist Hip Ratio, Body Mass Index and Free Testosterone Index (FTI) were calculated.
Results: 6908 women participated. The women on HRT had lower T and FTI and were less satisfied with mood and energy (p<0.05). Women with hot flushes had higher T and FTI and women reporting coldness had lower concentrations (p<0.05). Sexual well-being were not correlated to T or FTI (p>0.05).
Conclusions: Lower T concentrations were associated with lower quality of life in perimenopausal women but not to sexual well-being. There must be other factors than decrements in sex hormones that contribute to the emergence of some perimenopausal symptoms.
Place, publisher, year, edition, pages
2008. Vol. 11, no 4, 304-314 p.
climacteric, perimenopause, Testosterone, Androgens, Quality of Life
National CategoryMedical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-15615DOI: 10.1080/13697130802249769OAI: oai:DiVA.org:liu-15615DiVA: diva2:126771
Original publication: Anders Götmar, Mats Hammar, Mats Fredrikson, Göran Samsioe, Christina Nerbrand, Jonas Lidfeldt and Anna-Clara Spetz, Symptoms in peri- and postmenopausal women in relation to testosterone concentrations. Data fromThe Women's Health in the Lund Area (WHILA) study, 2008, Climacteric, (11), 4, 304-314.http://dx.doi.org/10.1080/13697130802249769. Copyright © Taylor & Francis Group, an informa business2008-11-212008-11-212009-08-18Bibliographically approved