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Exploring plasmonic coupling as a stimuli responsive contrast mechanism in multiphoton microscopy
Univ Gothenburg, Sweden.
Univ Gothenburg, Sweden.
Univ Gothenburg, Sweden.
Univ Gothenburg, Sweden; Fluicell AB, Sweden.
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2018 (English)In: PLASMONICS IN BIOLOGY AND MEDICINE XV, SPIE-INT SOC OPTICAL ENGINEERING , 2018, Vol. 10509, article id 1050907Conference paper, Published paper (Refereed)
Abstract [en]

A novel approach for optical biosensing can be obtained based multiphoton induced luminescence (MIL) and its dependence on plasmonic coupling. It has been shown that the proximity of spherical AuNPs determines the generation of MIL in far-field multiphoton laser scanning microscopy (MPM). A stimuli responsive contrast mediator with high sensitivity can be created by controlling the aggregated state of AuNP. In this study we explore a system based on spherical AuNPs functionalized with beta-cyclodextrin and multiple beta-D-lactose units (lacto-CD-AuNP). The aim of the beta-D- lactose units is to target cancer cells, based on overexpression of galectin3 (Gal-3) receptors. The results demonstrate that clustering of particles, and thereby MIL signal, was only acquired from tumor cell lines, i.e., SK-MEL-28 and A431, while not from normal keratinocytes (HEKn). Thus further studies should be undertaken to translate the concept to a preclinical setting.

Place, publisher, year, edition, pages
SPIE-INT SOC OPTICAL ENGINEERING , 2018. Vol. 10509, article id 1050907
Series
Progress in Biomedical Optics and Imaging, ISSN 1605-7422
Keywords [en]
Gold nanoparticles; multiphoton microscopy; biosensing; galactin-3; skin cancer; keratinocytes; multiphoton luminescence
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:liu:diva-153417DOI: 10.1117/12.2288677ISI: 000450861300005ISBN: 978-1-5106-1504-5 (electronic)ISBN: 978-1-5106-1503-8 (print)OAI: oai:DiVA.org:liu-153417DiVA, id: diva2:1271469
Conference
Conference on Plasmonics in Biology and Medicine XV
Note

Funding Agencies|Marie Curie Program [608407]; Swedish Research Council [621-2015-05002]

Available from: 2018-12-17 Created: 2018-12-17 Last updated: 2018-12-17

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CiteExportLink to record
Permanent link

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Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
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  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
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