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Tissue transglutaminase autoantibodies in children with newly diagnosed type 1 diabetes are related to human leukocyte antigen but not to islet autoantibodies: A Swedish nationwide prospective population-based cohort study
Department of Women’s and Children’s Health, Karolinska Institutet, Stockholm, Sweden.
Department of Women’s and Children’s Health, Karolinska Institutet, Stockholm, Sweden; Hepatology and Nutrition, Astrid Lindgren Children’s Hospital, Karolinska University Hospital, Stockholm, Sweden.
Department of Women’s and Children’s Health, Karolinska Institutet, Stockholm, Sweden; Pediatric Diabetes Clinic, Astrid Lindgren Children’s Hospital, Karolinska University Hospital, Stockholm, Sweden.
Department of clinical sciences, Lund University, Skåne University hospital, Malmö, Sweden.
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2018 (English)In: Autoimmunity, ISSN 0891-6934, E-ISSN 1607-842X, Vol. 51, no 5, p. 221-227Article in journal (Refereed) Published
Abstract [en]

Objectives: This study explored the association between tissue transglutaminase autoantibody (tTGA), high-risk human leucocyte antigen (HLA) genotypes and islet autoantibodies in children with newly diagnosed type 1 diabetes (T1D).

Patients and methods: Dried blood spots and serum samples were taken at diagnosis from children <18 years of age participating in Better Diabetes Diagnosis (BDD), a Swedish nationwide prospective cohort study of children newly diagnosed with T1D. We analyzed tTGA, high-risk HLA DQ2 and DQ8 (DQX is neither DQ2 nor DQ8) and islet auto-antibodies (GADA, IA-2A, IAA, and three variants of Zinc transporter; ZnT8W, ZnT8R, and ZnT8QA).

Results: Out of 2705 children diagnosed with T1D, 85 (3.1%) had positive tTGA and 63 (2.3%) had borderline values. The prevalence of tTGA was higher in children with the HLA genotypes DQ2/2, DQ2/X or DQ2/8 compared to those with DQ8/8 or DQ8/X (p = .00001) and those with DQX/X (p ≤ .00001). No significant differences were found in relation to islet autoantibodies or age at diagnosis, but the presence of tTGA was more common in girls than in boys (p = .018).

Conclusion: tTGA at T1D diagnosis (both positive and borderline values 5.4%) was higher in girls and in children homozygous for DQ2/2, followed by children heterozygous for DQ2. Only children with DQ2 and/or DQ8 had tTGA. HLA typing at the diagnosis of T1D can help to identify those without risk for CD.

Place, publisher, year, edition, pages
Taylor & Francis, 2018. Vol. 51, no 5, p. 221-227
Keywords [en]
Type 1 diabetes; celiac disease; tissue transglutaminase antibodies; human leukocyte antigen; islet autoantibodies
National Category
Rheumatology and Autoimmunity
Identifiers
URN: urn:nbn:se:liu:diva-153558DOI: 10.1080/08916934.2018.1494160ISI: 000451984900003PubMedID: 30444426Scopus ID: 2-s2.0-85057317962OAI: oai:DiVA.org:liu-153558DiVA, id: diva2:1273124
Note

Funding Agencies|Swedish Child Diabetes Foundation (Barndiabetesfonden); Region Skane; Sigurd and Elsa Golje Foundation; Sallskapet Baravard; Stiftelsen Samariten; HKH Kronprinsessan Lovisas Forening for Barnasjukvard

Available from: 2018-12-20 Created: 2018-12-20 Last updated: 2019-01-11Bibliographically approved

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Division of Children's and Women's healthFaculty of Medicine and Health SciencesH.K.H. Kronprinsessan Victorias barn- och ungdomssjukhus
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