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Association study on IL-4, IL-4R alpha and IL-13 genetic polymorphisms in Swedish patients with colorectal cancer
Reg Jonkoping Cty, Sweden.
Reg Jonkoping Cty, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Reg Jonkoping Cty, Sweden.
Linköping University, Department of Medical and Health Sciences, Division of Drug Research. Linköping University, Faculty of Medicine and Health Sciences.
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2018 (English)In: Clinica Chimica Acta, ISSN 0009-8981, E-ISSN 1873-3492, Vol. 487, p. 101-106Article in journal (Refereed) Published
Abstract [en]

Background: Interleukin 4 (IL-4) and interleukin 13 (IL-13) are anti-inflammatory and immunomodulatory cytokines which share a common cellular receptor IL4R alpha and are involved in the same signaling pathways. Our purpose was to assess whether genetic variants within IL-4, IL-13 and IL-4R alpha are associated with the risk or clinical outcome of colorectal cancer (CRC). Methods: Three single nucleotide polymorphisms (SNPs) were screened in 466 patients with CRC and 445 healthy controls. The selected SNPs were IL-4 SNP rs2243250, IL-4R alpha SNP rs1801275 and IL-13 SNP rs1800925. Results: We found that the genotype variant T/T in IL-13 gene was associated with a higher risk of CRC. Kaplan Meier analysis showed that the cancer specific survival differed between C/C and CT + TT for IL-4 SNP. Moreover, the carriers of the T allele were associated with the highest risk of CRC death with a hazard ratio (HR) of 1.57, 95% CI 1.06-2.36, p = -.024. The observed effect of the T allele was restricted to stage III patients. Conclusion: Our results indicate IL-13 SNP rs1800925 as a risk factor for CRC and that IL-4 SNP rs2243250 could be a useful prognostic marker in the follow-up and clinical management of patients with CRC especially in stage III disease.

Place, publisher, year, edition, pages
ELSEVIER SCIENCE BV , 2018. Vol. 487, p. 101-106
Keywords [en]
IL-4; IL-4R alpha; IL-13; SNP; Colorectal cancer
National Category
Gastroenterology and Hepatology
Identifiers
URN: urn:nbn:se:liu:diva-153521DOI: 10.1016/j.cca.2018.09.024ISI: 000451491300018PubMedID: 30227113OAI: oai:DiVA.org:liu-153521DiVA, id: diva2:1273265
Note

Funding Agencies|Foundation of Clinical Cancer Research, Jonkoping Sweden

Available from: 2018-12-20 Created: 2018-12-20 Last updated: 2018-12-20

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