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Individual Genetic Variation Might Predict Acute Skin Reactions in Women Undergoing Adjuvant Breast Cancer Radiotherapy
Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Ryhov Cty Hosp, Sweden.
Linköping University, Department of Medical and Health Sciences. Linköping University, Faculty of Medicine and Health Sciences. Reg Jonkoping Cty, Sweden.
Ryhov Cty Hosp, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Reg Jonkoping Cty, Sweden.
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2018 (English)In: Anticancer Research, ISSN 0250-7005, E-ISSN 1791-7530, Vol. 38, no 12, p. 6763-6770Article in journal (Refereed) Published
Abstract [en]

Adverse skin reactions during radiotherapy (RT) are common. The aim of this study was to explore whether genetic variation might be linked to acute radiation skin reactions (ARSR). Materials and Methods: One hundred and nineteen women undergoing adjuvant RT for breast cancer were included. The symptoms of itching, burning and irritation were self-reported twice using the visual analogue scale. Assessments used the Radiation Therapy Oncology Group scoring system for acute RT skin reaction (RTOG scale). Blood-based single nucleotide polymorphism (SNP) analysis was performed. Thirty SNPs of well-defined functional genes were investigated. Results: All women were assessed with ARSR. After RT, the women self-reported itching (n=97), burning (n=64) and irritation (n=96). Two SNPs in X-Ray Repair Cross Complementing 2 gene (XRCC2) rs2040639 and interferon gamma (IFNG) rs2069705 genes were found to be associated with ARSR. Conclusion: An association between two SNPs and ARSR was found. The possibility of using these SNPs as prognostic biomarkers for ARSR as tools to improve the care of patients needs further investigation.

Place, publisher, year, edition, pages
INT INST ANTICANCER RESEARCH , 2018. Vol. 38, no 12, p. 6763-6770
Keywords [en]
Radiotherapy; breast cancer; skin reactions; single nucleotide polymorphism
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:liu:diva-153515DOI: 10.21873/anticanres.13047ISI: 000451742800022PubMedID: 30504388OAI: oai:DiVA.org:liu-153515DiVA, id: diva2:1274625
Note

Funding Agencies|Uppsala University; Knut & Alice Wallenberg Foundation of Uppsala, Sweden; Foundation for Clinical Cancer Research in Jonkoping; Futurum Academy for Health and Care, Region Jonkoping County, Sweden; FORSS-Medical Research Council of Southeast Sweden

Available from: 2019-01-02 Created: 2019-01-02 Last updated: 2019-01-02

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Oliva, DelmyNilsson, MatsAndersson, Bengt-ÅkeLewin, NongnitLewin, Freddi
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Division of Surgery, Orthopedics and OncologyFaculty of Medicine and Health SciencesDepartment of Medical and Health SciencesDepartment of Clinical and Experimental Medicine
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