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Characterization of extended-spectrum -lactamase-producing Escherichia coli harboring mcr-1 and toxin genes from human fecal samples from China
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences.
Shandong Ctr Dis Control and Prevent, Peoples R China.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences.
Shandong Univ, Peoples R China.
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2018 (English)In: FUTURE COMPUTING ... the ... International Conference on Future Computational Technologies and Applications, ISSN 1746-0913, E-ISSN 1999-5903, Vol. 13, no 15, p. 1647-1656Article in journal (Refereed) Published
Abstract [en]

Aim: To characterize extended-spectrum -lactamase-producing Escherichia coli harboring the colistin resistance gene mcr-1 from human fecal samples collected in 2012 in a rural area of Shandong province, PR China. Materials amp; methods: Whole-genome sequencing and antimicrobial susceptibility testing was performed on 25 mcr-1-positive isolates to determine carriage of antibiotic resistance and virulence genes, diversity and antibiotic resistance profiles. Results: The isolates were highly genetically diverse and carried a large variety of different antibiotic resistance genes. The multidrug-resistance rate was high (96%). Virulence genes associated with intestinal pathogenic E. coli were carried by 32% of the isolates. Conclusion: Further monitoring of the epidemiological situation is necessary to ensure a preparedness for potential emergence of novel, difficult-to-treat strains and awareness of available treatment options.

Place, publisher, year, edition, pages
FUTURE MEDICINE LTD , 2018. Vol. 13, no 15, p. 1647-1656
Keywords [en]
antibiotic resistance; colistin; ESBL; Escherichia coli; intestinal pathogenic E; coli; mcr-1; whole-genome sequencing
National Category
Microbiology in the medical area
Identifiers
URN: urn:nbn:se:liu:diva-153698DOI: 10.2217/fmb-2018-0242ISI: 000453872500005PubMedID: 30489158OAI: oai:DiVA.org:liu-153698DiVA, id: diva2:1276204
Note

Funding Agencies|National Natural Science Foundation of China [71073098]; Swedish International Development Cooperation Agency; Swedish Institute for Communicable Disease Control [2010-001861]

Available from: 2019-01-07 Created: 2019-01-07 Last updated: 2019-05-01

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Berglund, BjörnTärnberg, MariaWelander, JennyNilsson, MaudNilsson, Lennart E
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Division of Microbiology and Molecular MedicineFaculty of Medicine and Health SciencesDivision of Neuro and Inflammation ScienceDepartment of Clinical Microbiology
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FUTURE COMPUTING ... the ... International Conference on Future Computational Technologies and Applications
Microbiology in the medical area

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