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Probiotics promoted head growth in extremely low birthweight infants in a double-blind placebo-controlled trial
Linköping University, Department of Clinical and Experimental Medicine, Division of Children's and Women's health. Linköping University, Faculty of Medicine and Health Sciences.
Department of Neonatology, Astrid Lindgren Children's Hospital, Karolinska University Hospital and Institute, Stockholm, Sweden.
Department of Neonatology, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden.
Department of Neonatology, Astrid Lindgren Children's Hospital, Karolinska University Hospital and Institute, Stockholm, Sweden.
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2019 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 108, no 1, p. 62-69Article in journal (Refereed) Published
Abstract [en]

Aim

This study evaluated if oral supplementation with the probiotic bacterium Lactobacillus reuteri DSM 17938 improved enteral feeding tolerance and growth rates in extremely low birthweight (ELBW) infants.

Method

A randomised, double‐blind, placebo‐controlled trial comprising 134 ELBW (<1000 g) infants born before gestational week 28 + 0. Daily supplementation of Lreuteri (1.25 × 108 bacteria/day) or placebo started within 3 days and continued until gestational week 36 + 0. Primary outcome was feeding tolerance and secondary outcome growth rate calculated as z‐score development.

Results

Feeding tolerance was similar in the probiotic and placebo group. Time to full enteral feeds was 15 days in both groups. The z‐score of the head circumference decreased in both groups from birth to day 28 of life, but it decreased less in the L. reuteri group compared to the placebo group: −1.2 SD (95% CI: −1.4 to −1.0) versus −1.7 SD (95% CI: −2.0 to −1.5; p = 0.001). Other growth parameters were similar in the study groups.

Conclusion

Lactobacillus reuteri did not reduce time to reach full enteral feeds in ELBW infants. The L. reuteri supplemented infants, however, had a better growth rate of the head during the first month of life.

Place, publisher, year, edition, pages
Wiley-Blackwell Publishing Inc., 2019. Vol. 108, no 1, p. 62-69
Keywords [en]
Feeding tolerance; Growth; Necrotising enterocolitis; Premature infants; Probiotics
National Category
Pediatrics
Identifiers
URN: urn:nbn:se:liu:diva-153661DOI: 10.1111/apa.14497ISI: 000452620600012PubMedID: 29999201Scopus ID: 2-s2.0-85052536038OAI: oai:DiVA.org:liu-153661DiVA, id: diva2:1276255
Note

Funding Agencies|Swedish Research Council [921.2014-7060]; Swedish Society for Medical Research; Swedish Society of Medicine; Research Council for the South-East Sweden; ALF Grants, Region Ostergotland; Ekhaga Foundation; BioGaia AB

Available from: 2019-01-07 Created: 2019-01-07 Last updated: 2019-06-04Bibliographically approved

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