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Detection of rotavirus- and norovirus-specific IgG memory B cells in tonsils
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences.
Vastervik Hosp, Sweden.
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2019 (English)In: Journal of Medical Virology, ISSN 0146-6615, E-ISSN 1096-9071, Vol. 91, no 2, p. 326-329Article in journal (Refereed) Published
Abstract [en]

Because rotavirus (RV) and norovirus (NoV) are transmitted through the fecal-oral route, tonsils due to their location within the oropharynx may sample or become infected with these viruses. We investigated if RV and NoV RNA/antigen, or virus-specific memory/plasma B cells can be detected in the tonsils. While neither RV/NoV antigen, nor genomic RNA was detected, 90% (27/30) of tonsils tested had RV- and NoV-specific IgG memory B cells. However, the mechanism explaining how these cells get there (whether because of local induction or homing after induction at other sites) and the role these cells might play during active infection is not yet clear.

Place, publisher, year, edition, pages
WILEY , 2019. Vol. 91, no 2, p. 326-329
Keywords [en]
B cells; ELISpot; norovirus (NoV); rotavirus (RV); tonsils
National Category
Immunology in the medical area
Identifiers
URN: urn:nbn:se:liu:diva-153644DOI: 10.1002/jmv.25247ISI: 000453029000020PubMedID: 29905954OAI: oai:DiVA.org:liu-153644DiVA, id: diva2:1276271
Note

Funding Agencies|Swedish Research Council [320301]; Swedish Foundation for Strategic Research

Available from: 2019-01-07 Created: 2019-01-07 Last updated: 2019-01-07

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Sharma, SumitHagbom, MarieNordgren, JohanHinkula, JormaLedin, TorbjörnSvensson, Lennart
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Division of Microbiology and Molecular MedicineFaculty of Medicine and Health SciencesDivision of Speech language pathology, Audiology and OtorhinolaryngologyDepartment of Otorhinolaryngology in Linköping
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