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Deep TMS of the insula using the H-coil modulates dopamine release: a crossover [C-11] PHNO-PET pilot trial in healthy humans
Ctr Addict and Mental Hlth, Canada.
Ctr Addict and Mental Hlth, Canada; Univ Toronto, Canada.
Ctr Addict and Mental Hlth, Canada; Univ Toronto, Canada.
Ctr Addict and Mental Hlth, Canada.
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2018 (English)In: Brain Imaging and Behavior, ISSN 1931-7557, E-ISSN 1931-7565, Vol. 12, no 5, p. 1306-1317Article in journal (Refereed) Published
Abstract [en]

Modulating the function of the insular cortex could be a novel therapeutic strategy to treat addiction to a variety of drugs of abuse as this region has been implicated in mediating drug reward and addictive processes. The recent advent of the H-coil has permitted the targeting of deeper brain structures which was not previously feasible. The goal of this study was to bilaterally target the insular region using the H-coil with repetitive Transcranial Magnetic Stimulation (rTMS) and subsequently measure changes in dopamine levels using Positron Emission Tomography (PET) with [11C]-(+)-propyl-hexahydro-naphtho-oxazin (PHNO). This was a within-subject, crossover, blinded and sham-controlled pilot study. Eight healthy, right-handed subjects, aged 19-45, participated in the investigation. All subjects underwent 3 PHNO-PET scans preceded by rTMS (sham, 1Hz or 10Hz), on 3 separate days. Low frequency rTMS (1Hz), targeting the insular cortex, significantly decreased dopamine levels in the substantia nigra, sensorimotor striatum and associative striatum. Replicating this study in tobacco smokers or alcoholics would be a logical follow-up to assess whether H-coil stimulation of the bilateral insula can be employed as a treatment option for addiction. Trial registration: NCT02212405

Place, publisher, year, edition, pages
SPRINGER , 2018. Vol. 12, no 5, p. 1306-1317
Keywords [en]
Insula; PET; Dopamine; H-coil; Deep rTMS; PHNO
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:liu:diva-153708DOI: 10.1007/s11682-017-9800-1ISI: 000452760300009PubMedID: 29170944OAI: oai:DiVA.org:liu-153708DiVA, id: diva2:1276275
Note

Funding Agencies|Campbell Family via the CAMH foundation fund [200]

Available from: 2019-01-07 Created: 2019-01-07 Last updated: 2019-01-07

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Heilig, Markus
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Center for Social and Affective NeuroscienceFaculty of Medicine and Health SciencesDepartment of Psychiatry
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