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Nasal nitric oxid and nasal nitrate and nitrite in relation to allergy and smoking habits
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Pediatrics .
Department of Pediatrics, Sahlgrenska Academy of Göteborg University, Göteborg, Sweden/Phadia AB, Uppsala, Sweden.
2008 (English)Article in journal (Refereed) Submitted
Abstract [en]

Background: The role of nasally exhaled nitric oxide (nNO) in diagnosis of allergic rhinitis is still unclear, in contrast to orally exhaled nitric oxide (eNO), which is well established as a marker of inflammation in the lower airways.

Objective: Levels of nNO, nitrite/nitrate in nasal lavage (NAL) and acoustic rhinometry results were analysed in order to evaluate these markers in allergic rhinitis.

Methods: Altogether 45 subjects were subgrouped according to airway into: allergy with ongoing allergen exposure (I) or in a latent phase of exposure (II) and no allergy (III). The level of nNO was calculated by subtraction of eNO after mouthwash from nasally exhaled NO. The findings were related to acoustic rhinometry and spirometry, before and after an exercise provocation of the airways. Nitrite/nitrate levels were analysed by the Greiss reaction after reduction of nitrate to nitrite.

Results: A weak correlation between nNO and nitrite/nitrate levels was found in males, but neither of these markers nor acoustic rhinometry showed differences between the subgroups. In contrast, eNO, but not spirometry, differentiated allergy with ongoing allergen exposure from allergy in a latent phase of exposure and no allergy.

Conclusions: No difference of nNO levels was found in allergic and normal subjects.

Place, publisher, year, edition, pages
2008.
Keyword
Nitic oxide, nitrite/nitrate, nasal mucosa, allergic rhinitis, smoking habits
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-15851OAI: oai:DiVA.org:liu-15851DiVA: diva2:127634
Available from: 2008-12-10 Created: 2008-12-09 Last updated: 2009-02-11Bibliographically approved
In thesis
1. An 18 year Follow-up of Allergy Development: Findings of Nasal Markers of Allergic Inflammation
Open this publication in new window or tab >>An 18 year Follow-up of Allergy Development: Findings of Nasal Markers of Allergic Inflammation
2008 (English)Licentiate thesis, comprehensive summary (Other academic)
Alternative title[sv]
En 18 års uppföljning av allergiutveckling : fynd av markörer i näsa vid allergisk inflammation
Abstract [en]

Background: In addition to the family history of allergy (FH), there is a need o find objective markers of allergy development as early in life as possible in order to focus preventive measurements on high risk infants. Rhinitis problems are common causes to morbidity in adults due to allergic as well as non-allergic mechanisms. Accurate diagnoses are essential for decisions of optimal management of the patients, but in non-allergic rhinitis groups there are no objective tests to verify the diagnosis, if this is needed.

Aims: The primary aim was to evaluate the occurrence of nasal metacromatic (MC) cells during infancy as predictors for allergy development in a group of high risk subjects from birth up to 18 years of age. Additional aims were to find and evaluate nasal markers with ability to differentiate between allergic rhinitis with and without current allergen exposure from normal controls.

Subjects and methods: New-borns (n = 67) with and without family histories of allergy were included, and during the first 18 months of life occurrence of nasal MC could be evaluated in 64 infants (33 positive/31 negative MC findings). The cohort was followed up for allergy development at the ages of 18 months, 6 years and 18 years. Nasal markers as MC, nasal NO, nitrite/nitrate in nasal lavage and acoustic rhinometry at the 18-years follow-up were related to the allergic manifestations at this age.

Results: Positive nasal MC findings during infancy predicted allergy development up to 18 years of age in 31/33 subjects (94 %), as compared to 37/44 with positive FH (84 %). Negative MC findings during infancy did not exclude the risk, as 15/31 developed allergy (48 %). At the 18-years follow-up the numbers of individuals with demonstrable MC were significantly higher (p = 0.01) in the group of individuals with allergy symptoms (16/30) compared to the group of individuals with no allergy (1/12). Nasal NO levels, nitrite/nitrate concentrations in nasal lavages and acoustic rhinometry did not differentiate the allergic groups from the normal group.

Conclusions: Positive nasal MC findings during infancy predicted allergy development up to 18 years of age, and the cell findings often preceded the allergic symptoms. The marker can not be used as a single predictor of allergy development due to negative MC findings in a high proportion of allergic subjects. Positive MC findings combined with positive FH resulted in the best the risk evaluation. Differences between groups with and without current allergen exposure and healthy controls were not found by means of acoustic rhinometry, nasal MC, nasal NO or nitrites/nitrates levels. Further research to find reliable nasal markers is needed.

Place, publisher, year, edition, pages
Linköping: Linköping University Electronic Press, 2008. 40 p.
Series
Linköping Studies in Health Sciences. Thesis, ISSN 1100-6013 ; 89
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-15853 (URN)978-91-7393-748-1 (ISBN)
Presentation
2008-12-03, Elsa Brändströms sal, Campus US, Linköpings Universitet , Linköping, 13:00 (Swedish)
Opponent
Supervisors
Available from: 2008-12-09 Created: 2008-12-09 Last updated: 2009-04-30Bibliographically approved

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Irander, Kristina

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