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Estimating costs and health outcomes of publicly funded tick-born encephalitis vaccination: A cost-effectiveness analysis
Karolinska Inst, Sweden.
Linköping University, Department of Medical and Health Sciences, Division of Health Care Analysis. Linköping University, Faculty of Medicine and Health Sciences.
Karolinska Inst, Sweden; Dept Communicable Dis Control and Prevent, Sweden.
Karolinska Inst, Sweden; Dept Communicable Dis Control and Prevent, Sweden.
2018 (English)In: Vaccine, ISSN 0264-410X, E-ISSN 1873-2518, Vol. 36, no 50, p. 7659-7665Article in journal (Refereed) Published
Abstract [en]

Background: The number of notified cases of Tick-Borne Encephalitis (TBE) in Sweden has been increasing the past years despite the increased use of TBE-vaccine not subsidized by the healthcare system. Stockholm County is a high endemic area and an earlier study has shown that low-income households have lower vaccination coverage even when they are at high risk. This paper aims to determine the cost-effectiveness of a publicly funded TBE vaccination program in Stockholm. Methods: In three different cohorts with individuals aged 3, 40 or 50 years, long-term costs and health outcomes of an out-of-pocket strategy (53% of the cohort is vaccinated on their own expenses) and a structured vaccination program (full cohort is vaccinated covered by the publicly funded health care system), were estimated using a Markov model. The Markov model predicts the costs and effects in term of Quality-adjusted Life Years (QALYs) over a lifetime horizon using a third-party healthcare payer perspective. The primary results are presented as an incremental cost effectiveness ratio (ICER) indicating the additional cost required to achieve one additional QALY with the structured vaccination program. Results: The results show that the structured vaccination program is associated with a gain in QALYs and increased costs compared with an out-of-pocket strategy. The calculated ICERs were 27 761, 99 527 and 160 827 SEK/QALY in cohorts of age 3, 40 and 50, respectively. The sensitivity analyses showed that the results are robust when varying different parameters. Conclusion: Given the setting of Stockholm county, this analysis shows a cost per QALY of a free vaccinations program, especially for children of 3 years old, below generally acceptable cost-effectiveness thresholds in Sweden. 

Place, publisher, year, edition, pages
ELSEVIER SCI LTD , 2018. Vol. 36, no 50, p. 7659-7665
Keywords [en]
TBE; Sweden; Cost-effectiveness; Policy; Costing
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
URN: urn:nbn:se:liu:diva-153831DOI: 10.1016/j.vaccine.2018.10.086ISI: 000454463800010PubMedID: 30385058OAI: oai:DiVA.org:liu-153831DiVA, id: diva2:1278040
Available from: 2019-01-11 Created: 2019-01-11 Last updated: 2019-11-11

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