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The S-wave angle identifies arrhythmogenic right ventricular cardiomyopathy in patients with electrocardiographically concealed disease phenotype
Lund Univ, Sweden; Penn State Milton S Hershey Med Ctr, PA USA; Univ Minnesota, MN USA.
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Cardiology in Linköping.
Lund Univ, Sweden.
Univ Colorado Denver, CO USA; Univ Colorado Denver, CO USA.
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2018 (English)In: Journal of Electrocardiology, ISSN 0022-0736, E-ISSN 1532-8430, Vol. 51, no 6, p. 1003-1008Article in journal (Refereed) Published
Abstract [en]

Background: Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) carries risk of sudden death. We hypothesize that the S-wave angle differentiates ARVD/C with otherwise normal electrocardiograms from controls. Materials and methods: All patients met Task Force 2010 definite ARVD/C criteria. ARVD/C patients without Task Force depolarization/repolarization criteria (-ECG) were compared to controls. Electrocardiogram measures of QRS duration, corrected QT interval, and measured angle between the upslope and downslope of the S-wave in V2, were assessed. Results: Definite ARVD/C was present in 155 patients (42.7 +/- 17.3 years, 68.4%male). -ECG ARVD/C patients (66 patients) were compared to 66 control patients (41.8 +/- 17.6 years, 65.2%male). Only the S-wave angle differentiated -ECG ARVD/C patients from controls (amp;lt;0.001) with AU the ROC curve of 0.77 (95%Cl 0.53 to 0.71) and odds ratio of 28.3 (95%Cl 6.4 to 125.5). Conclusion: ARVD/C may lead to development of subtle ECG abnormalities distinguishable using the S-wave angle prior to development of 2010 Taskforce ECG criteria. (C) 2018 Elsevier Inc. All rights reserved.

Place, publisher, year, edition, pages
CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS , 2018. Vol. 51, no 6, p. 1003-1008
Keywords [en]
Arrhythmogenic right ventricular cardiomyopathy; S-wave angle; ECG; Cascade screening
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:liu:diva-153983DOI: 10.1016/j.jelectrocard.2018.08.009ISI: 000454673900017PubMedID: 30497719OAI: oai:DiVA.org:liu-153983DiVA, id: diva2:1281105
Note

Funding Agencies|Swedish Heart Lung Foundation; Swedish National Health Service; SkAne University Hospital, Lund, Sweden

Available from: 2019-01-21 Created: 2019-01-21 Last updated: 2019-01-21

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Division of Cardiovascular MedicineFaculty of Medicine and Health SciencesDepartment of Cardiology in Linköping
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