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Most Women with Previous Gestational Diabetes Mellitus Have Impaired Glucose Metabolism after a Decade
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Endocrinology. Linköping University, Department of Clinical and Experimental Medicine.
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Endocrinology.
Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Endocrinology.
2018 (English)In: International Journal of Molecular Sciences, ISSN 1422-0067, E-ISSN 1422-0067, Vol. 19, no 12, article id 3724Article in journal (Refereed) Published
Abstract [en]

Of 1324 women diagnosed with gestational diabetes mellitus (GDM) in Sweden, 25% reported amp;gt;10 years after the delivery that they had developed diabetes mellitus. We assessed the long-term risk of all glucose metabolic abnormalities in a subgroup of these women. Women (n = 51) previously diagnosed with GDM by capillary blood glucose amp;gt;= 9.0 mmol/L (approximate to plasma glucose amp;gt;= 10.0 mmol/L) after a 2 h 75 g oral glucose tolerance test (OGTT) were included. All underwent a clinical and biochemical evaluation, including a second 2 h 75 g OGTT. Individuals with known type 1 diabetes were excluded. At the follow-up, 12/51 (24%) reported previously diagnosed type 2 diabetes. Another four cases were diagnosed after the second OGTT, increasing the prevalence to 16/51 cases (31%). Impaired fasting plasma glucose (IFG) was diagnosed in 13/51 women and impaired glucose tolerance (IGT) in 10/51 women, leaving only 12 women (24%) with normal glucose tolerance. In addition, 2/51 women had high levels of glutamic acid decarboxylase (GAD) antibodies; of these, one woman classified as type 2 diabetes was reclassified as type 1 diabetes, and the second GAD-positive woman was diagnosed with IGT. Of the women diagnosed with GDM by a 2 h 75 g OGTT, a large proportion had impaired glucose metabolism a decade later, including type 1 and type 2 diabetes.

Place, publisher, year, edition, pages
MDPI , 2018. Vol. 19, no 12, article id 3724
Keywords [en]
gestational diabetes mellitus; maternal obesity; insulin resistance; impaired fasting glucose; impaired glucose tolerance; OGTT; fasting glucose; proinsulin; C-peptide; autoimmunity
National Category
Obstetrics, Gynecology and Reproductive Medicine
Identifiers
URN: urn:nbn:se:liu:diva-154123DOI: 10.3390/ijms19123724ISI: 000455323500026PubMedID: 30477103OAI: oai:DiVA.org:liu-154123DiVA, id: diva2:1283640
Note

Funding Agencies|Medical Research Council of Southeast Sweden [5759, 9042]

Available from: 2019-01-29 Created: 2019-01-29 Last updated: 2019-05-01

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Wahlberg, JeanetteEkman, BertilArnqvist, Hans
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