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Bacteria-Host Crosstalk: Sensing of the Quorum in the Context of Pseudomonas aeruginosa Infections
Linköping University, Department of Clinical and Experimental Medicine, Divison of Neurobiology. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences.
2019 (English)In: Journal of Innate Immunity, ISSN 1662-811X, E-ISSN 1662-8128, Vol. 11, no 3, p. 263-279Article in journal (Refereed) Epub ahead of print
Abstract [en]

Cell-to-cell signaling via small molecules is an essential process to coordinate behavior in single species within a community, and also across kingdoms. In this review, we discuss the quorum sensing (QS) systems used by the opportunistic pathogen <i>Pseudomonas aeruginosa</i> to sense bacterial population density and fitness, and regulate virulence, biofilm development, metabolite acquisition, and mammalian host defense. We also focus on the role of <i>N</i>-acylhomoserine lactone-dependent QS signaling in the modulation of innate immune responses connected together via calcium signaling, homeostasis, mitochondrial and cytoskeletal dynamics, and governing transcriptional and proteomic responses of host cells. A future perspective emphasizes the need for multidisciplinary efforts to bring current knowledge of QS into a more detailed understanding of the communication between bacteria and host, as well as into strategies to prevent and treat <i>P. aeruginosa</i> infections and reduce the rate of antibiotic resistance.

Place, publisher, year, edition, pages
S. Karger, 2019. Vol. 11, no 3, p. 263-279
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-154613DOI: 10.1159/000494069ISI: 000467678500008OAI: oai:DiVA.org:liu-154613DiVA, id: diva2:1290825
Note

Funding agencies: Swedish Research Council; European Science Foundation (TraPPs Euromembrane project); Euro-BioImaging Proof-of Concept Studies; Faculty of Health Sciences, Linkoping University; Magnus Bergvalls Foundation

Available from: 2019-02-21 Created: 2019-02-21 Last updated: 2019-06-14

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Citation style
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