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Fc gamma-receptor polymorphisms associated with clinical symptoms in patients with immunoglobulin G subclass deficiency
Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Medicine and Health Sciences. Ryhov Cty Hosp, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Department of Clinical Immunology and Transfusion Medicine.
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Infectious Diseases.
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2018 (English)In: Infectious Diseases, ISSN 2374-4235, E-ISSN 2374-4243, Vol. 50, no 11-12, p. 853-858Article in journal (Refereed) Published
Abstract [en]

Background: Immunoglobulin G subclass deficiencies (IgGsd) are associated with recurrent respiratory tract infections. Immunoglobulin substitution therapy may be needed to prevent chronic lung tissue damage but tools for identifying the patients that will benefit from this treatment are still insufficient. Some Fc gamma R polymorphisms seem to predispose for an increased risk for infections. In this study we wanted to evaluate if the Fc gamma R-profile differs between individuals with IgGsd and a control population. Methods: Single nucleotide polymorphisms (SNPs) of Fc gamma RIIa, Fc gamma RIIIa and Fc gamma RIIc in 36 IgGsd patients and 192 controls with similar sex and geographical distribution were analyzed by TaqMan allelic discrimination assay or Sanger sequencing. Results: In the IgGsd-group, homozygous frequency for Fc gamma RIIa-R/R131 (low-binding capacity isoform) was higher (p = .03) as well as for non-classical Fc gamma RIIc-ORF (p = .03) and classical Fc gamma RIIc-ORF tended (p = .07) to be more common compared to the controls. There was no difference between the groups regarding Fc gamma RIIIa. Conclusion: The gene for classical Fc gamma RIIc-ORF tended to be more frequent in individuals with immunoglobulin G subclass deficiency and the genes for non-classical Fc gamma RIIc-ORF as well as low-binding capacity receptor Fc gamma RIIa-R/R131 were more frequent. Further studies on the Fc gamma R polymorphisms may pave way for identifying individuals that will benefit from immunoglobulin substitution.

Place, publisher, year, edition, pages
TAYLOR & FRANCIS LTD , 2018. Vol. 50, no 11-12, p. 853-858
Keywords [en]
Fc gamma-receptor; Polymorphism; Respiratory tract infection; Immunoglobulin G subclass deficiency
National Category
Infectious Medicine
Identifiers
URN: urn:nbn:se:liu:diva-154728DOI: 10.1080/23744235.2018.1510183ISI: 000457473500009PubMedID: 30298768OAI: oai:DiVA.org:liu-154728DiVA, id: diva2:1292256
Note

Funding Agencies|FORSS [forss-654371]; Futurum [futurum-709431]

Available from: 2019-02-27 Created: 2019-02-27 Last updated: 2019-04-24

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Wågström, PerYamada, NaomiDahle, CharlotteNilsdotter-Augustinsson, ÅsaSöderkvist, PeterBjörkander, Jan Fredrik
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Department of Clinical and Experimental MedicineFaculty of Medicine and Health SciencesDivision of Cell BiologyDivision of Neuro and Inflammation ScienceDepartment of Clinical Immunology and Transfusion MedicineDivision of Microbiology and Molecular MedicineDepartment of Infectious DiseasesClinical genetics
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