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Fixed Combination Antiemetic A literature review on prevention of chemotherapy-induced nausea and vomiting using netupitant/palonosetron
Univ Kansas, KS 66205 USA.
Alcura UK Ltd, England.
Linköping University, Department of Medical and Health Sciences, Division of Nursing Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Oncology.ORCID iD: 0000-0002-9786-7326
Univ Hosp Halle, Germany.
2018 (English)In: Clinical Journal of Oncology Nursing, ISSN 1092-1095, E-ISSN 1538-067X, Vol. 22, no 2, p. E52-E63Article, review/survey (Refereed) Published
Abstract [en]

BACKGROUND: Prevention of chemotherapy-induced nausea and vomiting (CINV) can be improved with guideline-consistent use of antiemetics. However, adherence to antiemetic guidelines remains often insufficient. Therefore, new strategies that improve adherence are needed. OBJECTIVES: To review the latest antiemetic guideline recommendations and provide an update on the use of NEPA, a fixed combination antiemetic composed of the neurokinin-1 receptor antagonist (RA) netupitant and the 5-hydroxytryptamine-3 RA palonosetron (Akynzeo (R)). METHODS: Analysis of the literature was performed, including guidelines, published literature, congress data on NEPA, and relevant articles on CINV. FINDINGS: Nurses are in a unique position to promote guideline-consistent antiemetic prophylaxis and are central in the education of patients and caregivers. Thus, nurses continuous education on antiemetic treatments is key for the prevention and management of CINV. NEPA offers a simplified antiemetic therapy with the potential to increase guideline adherence.

Place, publisher, year, edition, pages
ONCOLOGY NURSING SOC , 2018. Vol. 22, no 2, p. E52-E63
Keywords [en]
chemotherapy-induced nausea and vomiting; antiemetic guidelines; NEPA
National Category
Nursing
Identifiers
URN: urn:nbn:se:liu:diva-155024DOI: 10.1188/18.CJON.E52-E63ISI: 000459301800004PubMedID: 29547597OAI: oai:DiVA.org:liu-155024DiVA, id: diva2:1294808
Note

Funding Agencies|Helsinn Healthcare SA; Eisai; Helsinn

Available from: 2019-03-08 Created: 2019-03-08 Last updated: 2019-03-08

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