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Reactivation of a developmental Bmp2 signaling center is required for therapeutic control of the murine periosteal niche
Harvard Sch Dent Med, MA 02115 USA; Univ Zurich, Switzerland.
Harvard Sch Dent Med, MA 02115 USA; Univ Fed Sao Paulo, Brazil.
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Univ Zurich, Switzerland.
Univ Zurich, Switzerland.
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2019 (English)In: eLIFE, E-ISSN 2050-084X, Vol. 8, article id e42386Article in journal (Refereed) Published
Abstract [en]

Two decades after signals controlling bone length were discovered, the endogenous ligands determining bone width remain unknown. We show that postnatal establishment of normal bone width in mice, as mediated by bone-forming activity of the periosteum, requires BMP signaling at the innermost layer of the periosteal niche. This developmental signaling center becomes quiescent during adult life. Its reactivation however, is necessary for periosteal growth, enhanced bone strength, and accelerated fracture repair in response to bone-anabolic therapies used in clinical orthopedic settings. Although many BMPs are expressed in bone, periosteal BMP signaling and bone formation require only Bmp2 in the Prx1-Cre lineage. Mechanistically, BMP2 functions downstream of Lrp5/6 pathway to activate a conserved regulatory element upstream of Sp7 via recruitment of Smad1 and Grhl3. Consistent with our findings, human variants of BMP2 and GRHL3 are associated with increased risk of fractures.

Place, publisher, year, edition, pages
ELIFE SCIENCES PUBLICATIONS LTD , 2019. Vol. 8, article id e42386
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
URN: urn:nbn:se:liu:diva-155005DOI: 10.7554/eLife.42386ISI: 000459460100001PubMedID: 30735122OAI: oai:DiVA.org:liu-155005DiVA, id: diva2:1297527
Note

Funding Agencies|National Institute of Arthritis and Musculoskeletal and Skin Diseases [R01 AR055904]

Available from: 2019-03-20 Created: 2019-03-20 Last updated: 2019-08-22

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Cantù, Claudio
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