liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Incidence of Capillary Leak Syndrome as an Adverse Effect of Drugs in Cancer Patients: A Systematic Review and Meta-Analysis
Gyeongsang Natl Univ, South Korea.
Yonsei Univ, South Korea; Severance Childrens Hosp, South Korea; Yonsei Univ, South Korea.
Yonsei Univ, South Korea; Severance Childrens Hosp, South Korea.
Wonkwang Univ, South Korea.
Show others and affiliations
2019 (English)In: JOURNAL OF CLINICAL MEDICINE, ISSN 2077-0383, Vol. 8, no 2, article id 143Article, review/survey (Refereed) Published
Abstract [en]

Capillary leak syndrome (CLS) is a rare disease with profound vascular leakage, which can be associated with a high mortality. There have been several reports on CLS as an adverse effect of anti-cancer agents and therapy, but the incidence of CLS according to the kinds of anti-cancer drugs has not been systemically evaluated. Thus, the aim of our study was to comprehensively meta-analyze the incidence of CLS by different types of cancer treatment or after bone marrow transplantation (BMT). We searched the literatures (inception to July 2018) and among 4612 articles, 62 clinical trials (studies) were eligible. We extracted the number of patients with CLS, total cancer patients, name of therapeutic agent and dose, and type of cancer. We performed a meta-analysis to estimate the summary effects with 95% confidence interval and between-study heterogeneity. The reported incidence of CLS was categorized by causative drugs and BMT. The largest number of studies reported on CLS incidence during interleukin-2 (IL-2) treatment (n = 18), which yielded a pooled incidence of 34.7% by overall estimation and 43.9% by meta-analysis. The second largest number of studies reported on anti-cluster of differentiation (anti-CD) agents (n = 13) (incidence of 33.9% by overall estimation and 35.6% by meta-analysis) or undergoing BMT (n = 7 (21.1% by overall estimation and 21.7% by meta-analysis). Also, anti-cancer agents, including IL-2 + imatinib mesylate (three studies) and anti-CD22 monoclinal antibodies (mAb) (four studies), showed a dose-dependent increase in the incidence of CLS. Our study is the first to provide an informative overview on the incidence rate of reported CLS patients as an adverse event of anti-cancer treatment. This meta-analysis can lead to a better understanding of CLS and assist physicians in identifying the presence of CLS early in the disease course to improve the outcome and optimize management.

Place, publisher, year, edition, pages
MDPI , 2019. Vol. 8, no 2, article id 143
Keywords [en]
capillary leak syndrome; cancer; interleukin-2; anti-CD agents; bone marrow transplantation
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:liu:diva-155590DOI: 10.3390/jcm8020143ISI: 000460295400016PubMedID: 30691103OAI: oai:DiVA.org:liu-155590DiVA, id: diva2:1297820
Available from: 2019-03-21 Created: 2019-03-21 Last updated: 2019-09-11

Open Access in DiVA

fulltext(1233 kB)29 downloads
File information
File name FULLTEXT01.pdfFile size 1233 kBChecksum SHA-512
03ccab743fd29141e85879980b8ffc659a666dab4bcd31e841845ea52f1f2adf34b1366bc9c2b4330ee3586cf7d78c5618f633d6320a3a0ae5e1b8cda864cc2b
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Dragioti, Elena
By organisation
Division of Community MedicineFaculty of Medicine and Health Sciences
Cancer and Oncology

Search outside of DiVA

GoogleGoogle Scholar
Total: 29 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 31 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf