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Scandinavian Multicenter Acute Subdural Hematoma (SMASH) Study: Study Protocol for a Multinational Population-Based Consecutive Cohort
Copenhagen Univ Hosp, Denmark; Karolinska Univ Hosp, Sweden.
Copenhagen Univ Hosp, Denmark.
Karolinska Univ Hosp, Sweden.
Odense Univ Hosp, Denmark.
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2019 (English)In: Neurosurgery, ISSN 0148-396X, E-ISSN 1524-4040, Vol. 84, no 3, p. 799-803Article in journal (Refereed) Published
Abstract [en]

BACKGROUND Traumatic acute subdural hematomas (ASDHs) are associated with high rate of morbidity and mortality, especially in elderly individuals. However, recent reports indicate that the morbidity and mortality rates might have improved. OBJECTIVE To evaluate postoperative (30-d) mortality in younger vs elderly (70 yr) patients with ASDH. Comparing younger and elderly patients, the secondary objectives are morbidity patterns of care and 6 mo outcome according to Glasgow outcome scale (GOS). Finally, in patients with traumatic ASDH, we aim to provide prognostic variables. METHODS This is a large-scale population-based Scandinavian study including all neurosurgical departments in Denmark and Sweden. All adult (18 yr) patients surgically treated between 2010 and 2014 for a traumatic ASDH in Denmark and Sweden will be included. Identification at clinicaltrials.gov is NCT03284190. EXPECTED OUTCOMES We expect to provide data on potential differences between younger vs elderly patients in terms of mortality and morbidity. We hypothesize that elderly patients selected for surgery have a similar pattern of care as compared with younger patients. We will provide functional outcome in terms of GOS at 6 mo in younger vs elderly patients undergoing ASDH evacuation. Finally, clinical useful prognostic factors for favorable (GOS 4-5) vs unfavorable (GOS 1-3) will be identified. DISCUSSION An improved understanding of the clinical outcome, treatment and resource allocation, clinical course, and the prognostic factors of traumatic ASDH will allow neurosurgeons to make better treatment decisions.

Place, publisher, year, edition, pages
OXFORD UNIV PRESS INC , 2019. Vol. 84, no 3, p. 799-803
Keywords [en]
Acute subdural hematoma; Outcome; Elderly; Predictors
National Category
Surgery
Identifiers
URN: urn:nbn:se:liu:diva-155539DOI: 10.1093/neuros/nyy173ISI: 000460636600076PubMedID: 29762769OAI: oai:DiVA.org:liu-155539DiVA, id: diva2:1299399
Available from: 2019-03-26 Created: 2019-03-26 Last updated: 2019-03-26

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Tobieson, LovisaCarlsvärd, Björn
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Division of Neuro and Inflammation ScienceFaculty of Medicine and Health SciencesDepartment of Neurosurgery
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