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Accounting for Two Forms of Hypoxia for Predicting Tumour Control Probability in Radiotherapy: An In Silico Study
Department of Physics, Stockholm University, Stockholm, Sweden.
Department of Physics, Stockholm University, Stockholm, Sweden / Department of Oncology and Pathology, Karolinska Institutet, Solna, Sweden.
Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Faculty of Medicine and Health Sciences. The Skandion Clinic, Uppsala, Sweden.ORCID iD: 0000-0001-8171-2541
2018 (English)In: Oxygen Transport to Tissue XL / [ed] Oliver Thews, Joseph C. LaManna and David K. Harrison, Cham: Springer, 2018, Vol. 1072, p. 183-187Chapter in book (Refereed)
Abstract [en]

The progress in functional imaging and dose delivery has opened the possibility of targeting tumour hypoxia with radiotherapy. Advanced approaches apply quantitative information on tumour oxygenation retrieved from imaging in dose prescription. These do not, however, take into account the potential difference in radiosensitivity of chronically and acutely hypoxic cells. It was the aim of this study to evaluate the implications of assuming the same or different sensitivities for the hypoxic cells. An in silico 3D-model of a hypoxic tumour with heterogeneous oxygenation was used to model the probabilities of tumour control with different radiotherapy regimens. The results show that by taking into account the potential lower radioresistance of chronically hypoxic cells deprived of oxygen and nutrients, the total dose required to achieve a certain level of control is substantially reduced for a given fractionation scheme in comparison to the case when chronically and acutely hypoxic cells are assumed to have similar features. The results also suggest that the presence of chronic hypoxia could explain the success of radiotherapy for some hypoxic tumours. Given the implications for clinical dose escalation trials, further exploration of the influence of the different forms of hypoxia on treatment outcome is therefore warranted.

Place, publisher, year, edition, pages
Cham: Springer, 2018. Vol. 1072, p. 183-187
Series
Advances in Experimental Medicine and Biology, ISSN 0065-2598, E-ISSN 2214-8019 ; 1072
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:liu:diva-152509DOI: 10.1007/978-3-319-91287-5_29PubMedID: 30178343ISBN: 9783319912851 (print)ISBN: 9783319912875 (print)OAI: oai:DiVA.org:liu-152509DiVA, id: diva2:1299662
Available from: 2019-03-28 Created: 2019-03-28 Last updated: 2019-04-08

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Dasu, Alexandru

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CiteExportLink to record
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