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Effects of thoracic epidural analgesia on exercise-induced myocardial ischaemia in refractory angina pectoris
Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden.
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Cardiology in Linköping.
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Thoracic and Vascular Surgery.
Karolinska Univ Hosp, Sweden.
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2019 (English)In: Acta Anaesthesiologica Scandinavica, ISSN 0001-5172, E-ISSN 1399-6576, Vol. 63, no 4, p. 515-522Article in journal (Refereed) Published
Abstract [en]

Background Thoracic epidural analgesia (TEDA) was offered to patients with refractory angina pectoris. Our primary objectives were to evaluate TEDAs influence on quality of life (QoL, base for power analysis), and hypothesising that TEDA with bupivacaine during 1 month counteracts exercise-induced myocardial hypoperfusion and increase physical performance. Methods Patients with refractory angina and exercise inducible hypoperfusion, as demonstrated by myocardial perfusion imaging (MPI), were randomised to 1-month treatment with TEDA with bupivacaine (B-group, n = 9) or saline (P-group, n = 10) in a double-blind fashion. MPI and bicycle ergometry were performed before TEDA and after 1 month while subjective QoL on a visual analogue scale (VAS) reported by the patients was checked weekly. Results During this month VAS (mean [95%CI]) increased similarly in both groups (B-group from 33 [18-50] to 54 [30-78] P P amp;lt; 0.05). The B-group reduced their exertional-induced myocardial hypoperfusion (from 32% [12-52] to 21% [3-39]; n = 9; P amp;lt; 0.05), while the P-group showed no significant change (before 21% [6-35]; at 1 month 23% [6-40]; n = 10). MPI at rest did not change and no improvement in physical performance was detected in neither of the groups. Conclusions In refractory angina, TEDA with bupivacaine inhibits myocardial ischaemia in contrast to TEDA with saline. Regardless of whether bupivacaine or saline is applied intermittently every day, TEDA during 1 month improves the quality of life and reduces angina, even when physical performance remains low. A significant placebo effect has to be considered.

Place, publisher, year, edition, pages
WILEY , 2019. Vol. 63, no 4, p. 515-522
Keywords [en]
anti-ischaemic effect; myocardial scintigraphy; placebo-controlled study; quality of life; refractory angina pectoris; thoracic epidural analgesia
National Category
Physiotherapy
Identifiers
URN: urn:nbn:se:liu:diva-155522DOI: 10.1111/aas.13291ISI: 000460657800014PubMedID: 30374950OAI: oai:DiVA.org:liu-155522DiVA, id: diva2:1300659
Note

Funding Agencies|Karolinska Institutet; County Council of Ostergotland

Available from: 2019-03-29 Created: 2019-03-29 Last updated: 2019-03-29

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Richter, ArinaCederholm, IngemarMilovanovic, Micha
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Division of Cardiovascular MedicineFaculty of Medicine and Health SciencesDepartment of Cardiology in LinköpingDepartment of Thoracic and Vascular SurgeryDivision of Nursing ScienceDepartment of Internal Medicine in Norrköping
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Acta Anaesthesiologica Scandinavica
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