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Is there a relationship between anaesthesia and dementia?
Linköping University, Department of Medical and Health Sciences. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences.
Karolinska Inst, Sweden; Lund Univ, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences.ORCID iD: 0000-0002-8234-5461
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2019 (English)In: Acta Anaesthesiologica Scandinavica, ISSN 0001-5172, E-ISSN 1399-6576, Vol. 63, no 4, p. 440-447Article in journal (Refereed) Published
Abstract [en]

Background

Long‐term cognitive problems are common among elderly patients after surgery, and it has been suggested that inhalation anaesthetics play a role in the development of dementia. This study aims to investigate the hypothesis that patients with dementia have been more exposed to surgery and inhalational anaesthetics than individuals without dementia.

Methods

Using 457 cases from a dementia‐registry and 420 dementia‐free controls, we performed a retrospective case‐control study. The medical records were reviewed to determine exposure to anaesthesia occurring within a 20‐year timeframe before the diagnosis or inclusion in the study. Data were analysed using multivariate logistic regression and propensity score analysis.

Results

Advanced age (70 years and older, with the highest risk in ages 80‐84 years) and previous head trauma were risk factors for dementia. History of exposure to surgery with anaesthesia was a risk factor for dementia (OR = 2.23, 95% CI 1.66‐3.00, P < 0.01). Exposure to inhalational anaesthetics with halogenated anaesthetics was associated with an increased risk of dementia, compared to no exposure to anaesthesia (OR = 2.47, 95% CI 1.17‐5.22, P = 0.02). Exposure to regional anaesthesia was not significantly associated with increased risk of dementia (P = 0.13).

Conclusion

In this 20‐year retrospective case‐control study, we found a potential association between dementia and prior anaesthesia. Exposure to general anaesthetics with halogenated anaesthetic gases was associated with an increased risk of dementia.

Place, publisher, year, edition, pages
Wiley-Blackwell Publishing Inc., 2019. Vol. 63, no 4, p. 440-447
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:liu:diva-155521DOI: 10.1111/aas.13302ISI: 000460657800004PubMedID: 30511411Scopus ID: 2-s2.0-85058028192OAI: oai:DiVA.org:liu-155521DiVA, id: diva2:1300664
Note

Funding Agencies|County Council of Ostergotland, Sweden

Available from: 2019-03-29 Created: 2019-03-29 Last updated: 2019-04-03Bibliographically approved

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Strand, Anna-KarinNyqvist, FredrikWingren, GunEintrei, Christina
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Department of Medical and Health SciencesFaculty of Medicine and Health SciencesDivision of Neuro and Inflammation ScienceDivision of Drug ResearchDepartment of Anaesthesiology and Intensive Care in Linköping
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Acta Anaesthesiologica Scandinavica
Cardiac and Cardiovascular Systems

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