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Conceptual Design of Micro-Bioreactors and Organ-on-Chips for Studies of Cell Cultures
Linköping University, Department of Physics, Chemistry and Biology, Biotechnology. Linköping University, Faculty of Science & Engineering.ORCID iD: 0000-0001-9711-794X
2018 (English)In: Bioengineering (Basel, Switzerland), ISSN 2306-5354, Vol. 5, no 3, article id 56Article, review/survey (Refereed) Published
Abstract [en]

Engineering design of microbioreactors (MBRs) and organ-on-chip (OoC) devices can take advantage of established design science theory, in which systematic evaluation of functional concepts and user requirements are analyzed. This is commonly referred to as a conceptual design. This review article compares how common conceptual design principles are applicable to MBR and OoC devices. The complexity of this design, which is exemplified by MBRs for scaled-down cell cultures in bioprocess development and drug testing in OoCs for heart and eye, is discussed and compared with previous design solutions of MBRs and OoCs, from the perspective of how similarities in understanding design from functionality and user purpose perspectives can more efficiently be exploited. The review can serve as a guideline and help the future design of MBR and OoC devices for cell culture studies.

Place, publisher, year, edition, pages
MDPI, 2018. Vol. 5, no 3, article id 56
Keywords [en]
biomechatronic design; bioprocess development; drug testing; eye-on-a-chip; heart-on-a-chip; in vitro assay; toxicity testing
National Category
Human Computer Interaction
Identifiers
URN: urn:nbn:se:liu:diva-155991DOI: 10.3390/bioengineering5030056PubMedID: 30029542OAI: oai:DiVA.org:liu-155991DiVA, id: diva2:1301165
Available from: 2019-04-01 Created: 2019-04-01 Last updated: 2019-10-09

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Mandenius, Carl-Fredrik
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CiteExportLink to record
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Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
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More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
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  • Other locale
More languages
Output format
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