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Neural Correlates of Compulsive Alcohol Seeking in Heavy Drinkers
Clinical NeuroImaging Research Core, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland; Department of Neuroscience, Brown University, Providence, Rhode Island, USA.
Clinical NeuroImaging Research Core, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA.
Clinical NeuroImaging Research Core, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA.
Clinical NeuroImaging Research Core, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA.
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2018 (English)In: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, ISSN 2451-9022, Vol. 3, no 12, p. 1022-1031Article in journal (Refereed) Published
Abstract [en]

Compulsive alcohol use, the tendency to continue alcohol seeking and taking despite negative consequences, is a hallmark of alcohol use disorder. Preclinical rodent studies have suggested a role for the medial prefrontal cortex, anterior insula, and nucleus accumbens in compulsive alcohol seeking. It is presently unknown whether these findings translate to humans. We used a novel functional magnetic resonance imaging paradigm and tested the hypothesis that heavy drinkers would compulsively seek alcohol despite the risk of an aversive consequence, and that this behavior would be associated with the activity of frontostriatal circuitry.

Place, publisher, year, edition, pages
Elsevier, 2018. Vol. 3, no 12, p. 1022-1031
Keywords [en]
Alcohol use disorder; Anterior insula; Compulsivity; Medial prefrontal cortex; Neuroimaging; Nucleus accumbens
National Category
Substance Abuse
Identifiers
URN: urn:nbn:se:liu:diva-155988DOI: 10.1016/j.bpsc.2018.06.009PubMedID: 30143454OAI: oai:DiVA.org:liu-155988DiVA, id: diva2:1301174
Available from: 2019-04-01 Created: 2019-04-01 Last updated: 2019-04-01

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Heilig, Markus

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Center for Social and Affective NeuroscienceFaculty of Medicine and Health SciencesDepartment of Psychiatry
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CiteExportLink to record
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Citation style
  • apa
  • harvard1
  • ieee
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  • vancouver
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  • Other style
More styles
Language
  • de-DE
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  • en-US
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Output format
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