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Investigating the Role of Radixin in Modulation of Stereocilia Length and Stiffness
Linköping University, Department of Clinical and Experimental Medicine, Divison of Neurobiology. Linköping University, Faculty of Medicine and Health Sciences.ORCID iD: 0000-0002-4455-5097
Linköping University, Department of Clinical and Experimental Medicine, Divison of Neurobiology. Linköping University, Faculty of Medicine and Health Sciences.
2018 (English)In: TO THE EAR AND BACK AGAIN - ADVANCES IN AUDITORY BIOPHYSICS, AMER INST PHYSICS , 2018, Vol. 1965, article id UNSP 060007Conference paper, Published paper (Refereed)
Abstract [en]

Mammalian hearing depends on deflection of stereocilia on the sensory outer hair cells of the inner ear. Previous data indicate that the stiffness of outer hair cell stereocilia are actively regulated. The molecular mechanism that regulate the deflection of stereocilia are presently less known. The aim of the study is to investigate the mechanistic pathway that underlie the stiffness modulation of outer hair cell stereocilia. Our hypothesis is that the membrane-cytoskeleton linker protein radixin, which is present at high concentration in stereocilia, could contribute to stiffness regulation. To test this hypothesis, we use the radixin blocker DX-52-1 which binds strongly and specifically to radixin. Time-resolved confocal imaging was used to visualize the sound-evoked motion of stereocilia in a semi-intact preparation of the guinea pig temporal bone. Cochlear microphonic potentials were also measured, using electrodes positioned in scala media. We found that the DX-52-1 inhibitor leads to an increase in stereocilia movements and decline in the amplitude of the cochlear microphonic potential. However, DX-52-1 caused a paradoxical increase in electromotility. These results suggest that radixin has a functionally important regulatory role in the mature inner ear.

Place, publisher, year, edition, pages
AMER INST PHYSICS , 2018. Vol. 1965, article id UNSP 060007
Series
AIP Conference Proceedings, ISSN 0094-243X
National Category
Biophysics
Identifiers
URN: urn:nbn:se:liu:diva-155956DOI: 10.1063/1.5038480ISI: 000461049900033ISBN: 978-0-7354-1670-3 (print)OAI: oai:DiVA.org:liu-155956DiVA, id: diva2:1301275
Conference
13th Mechanics of Hearing Workshop (MoH) on To Ear and Back Again - Advances in Auditory Biophysics
Note

Funding Agencies|Swedish Research Council; Soderberg Foundation; County Council of Ostergotland

Available from: 2019-04-01 Created: 2019-04-01 Last updated: 2019-10-25

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CiteExportLink to record
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  • apa
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