liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Corticosteroids protect infected cells against mycobacterial killing in vitro
Umea Univ, Sweden.
Umea Univ, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences.
Not Found:Linkoping Univ, Dept Clin and Expt Med, SE-58183 Linkoping, Sweden.
Show others and affiliations
2019 (English)In: Biochemical and Biophysical Research Communications - BBRC, ISSN 0006-291X, E-ISSN 1090-2104, Vol. 511, no 1, p. 117-121Article in journal (Refereed) Published
Abstract [en]

The effect of corticosteroids on human physiology is complex and their use in tuberculosis patients remains controversial. In a high-throughput screening approach designed to discover virulence inhibitors, several corticosteroids were found to prevent cytolysis of fibroblasts infected with mycobacteria. Further experiments with Mycobacterium tuberculosis showed anti-cytolytic activity in the 10 nM range, but no effect on bacterial growth or survival in the absence of host cells at 20 mu M. The results from a panel of corticosteroids with various affinities to the glucocorticoid- and mineralocorticoid receptors indicate that the inhibition of cytolysis most likely is mediated through the glucocorticoid receptor. Using live-imaging of M. tuberculosis-infected human monocyte-derived macrophages, we also show that corticosteroids to some extent control intracellular bacteria. In vitro systems with reduced complexity are to further study and understand the interactions between bacterial infection, immune defense and cell signaling. (C) 2019 The Authors. Published by Elsevier Inc.

Place, publisher, year, edition, pages
ACADEMIC PRESS INC ELSEVIER SCIENCE , 2019. Vol. 511, no 1, p. 117-121
Keywords [en]
Mycobacterium; Tuberculosis; Corticosteroids; Cell death; Drug discovery
National Category
Immunology
Identifiers
URN: urn:nbn:se:liu:diva-155934DOI: 10.1016/j.bbrc.2019.02.044ISI: 000460849800019PubMedID: 30773257OAI: oai:DiVA.org:liu-155934DiVA, id: diva2:1301301
Note

Funding Agencies|Swedish Research Council [2013-02030]; Swedish Innovation Agency [2013-02030]; Department of Biotechnology in India [2013-02030]; Kempe Foundations [SMK-1648]; Clas Groschinsky foundation [M16 35]; Laboratories for Chemical Biology Limed, a part of Chemical Biology Consortium Sweden

Available from: 2019-04-01 Created: 2019-04-01 Last updated: 2019-10-25

Open Access in DiVA

fulltext(1465 kB)25 downloads
File information
File name FULLTEXT01.pdfFile size 1465 kBChecksum SHA-512
59b1d39f87b8d2df5f670f1230cb7931496a83bb33657998d1cd03536104442df119f14efbbc12fd985da23d6d2ff9991aebc0fae4bc541bbb0fb09ebf53fa9a
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Kalsum, SadafLerm, Maria
By organisation
Division of Microbiology and Molecular MedicineFaculty of Medicine and Health Sciences
In the same journal
Biochemical and Biophysical Research Communications - BBRC
Immunology

Search outside of DiVA

GoogleGoogle Scholar
Total: 25 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 39 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf