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Control of hearing sensitivity by tectorial membrane calcium
Linköping University, Department of Clinical and Experimental Medicine, Divison of Neurobiology. Linköping University, Faculty of Medicine and Health Sciences. Columbia Univ, NY 10032 USA.
Linköping University, Department of Clinical and Experimental Medicine, Divison of Neurobiology. Linköping University, Faculty of Medicine and Health Sciences.ORCID iD: 0000-0002-4455-5097
Linköping University, Department of Clinical and Experimental Medicine, Divison of Neurobiology. Linköping University, Faculty of Medicine and Health Sciences.ORCID iD: 0000-0001-9615-3885
Linköping University, Department of Clinical and Experimental Medicine, Divison of Neurobiology. Linköping University, Faculty of Medicine and Health Sciences.
2019 (English)In: Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, E-ISSN 1091-6490, Vol. 116, no 12, p. 5756-5764Article in journal (Refereed) Published
Abstract [en]

When sound stimulates the stereocilia on the sensory cells in the hearing organ, Ca2+ ions flow through mechanically gated ion channels. This Ca2+ influx is thought to be important for ensuring that the mechanically gated channels operate within their most sensitive response region, setting the fraction of channels open at rest, and possibly for the continued maintenance of stereocilia. Since the extracellular Ca2+ concentration will affect the amount of Ca2+ entering during stimulation, it is important to determine the level of the ion close to the sensory cells. Using fluorescence imaging and fluorescence correlation spectroscopy, we measured the Ca2+ concentration near guinea pig stereocilia in situ. Surprisingly, we found that an acellular accessory structure close to the stereocilia, the tectorial membrane, had much higher Ca2+ than the surrounding fluid. Loud sounds depleted Ca2+ from the tectorial membrane, and Ca2+ manipulations had large effects on hair cell function. Hence, the tectorial membrane contributes to control of hearing sensitivity by influencing the ionic environment around the stereocilia.

Place, publisher, year, edition, pages
NATL ACAD SCIENCES , 2019. Vol. 116, no 12, p. 5756-5764
Keywords [en]
hearing; temporary threshold shift; mechanoelectrical transduction; tectorial membrane; calcium
National Category
Biophysics
Identifiers
URN: urn:nbn:se:liu:diva-156097DOI: 10.1073/pnas.1805223116ISI: 000461679000083PubMedID: 30837312OAI: oai:DiVA.org:liu-156097DiVA, id: diva2:1302144
Note

Funding Agencies|Swedish Research Council [2013-03403, 2017-06092]; Torsten Soderberg Foundation; Tysta Skolan Foundation; AFA Forsakrings AB; County Council of Ostergotland; US National Institute on Deafness and Other Communication Disorders [DC 00141]; Wenner-Gren Foundation

Available from: 2019-04-03 Created: 2019-04-03 Last updated: 2019-10-25

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