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Possible Role and Therapeutic Target of PDGF-D Signalling in Colorectal Cancer
Linköping University, Department of Medical and Health Sciences, Division of Drug Research. Linköping University, Faculty of Medicine and Health Sciences. Dept Lab Med, Sweden.
Jonkoping Univ, Sweden.
Helmholtz Ctr Infect Res, Germany.
Linköping University, Department of Medical and Health Sciences, Division of Drug Research. Linköping University, Faculty of Medicine and Health Sciences.
2019 (English)In: Cancer Investigation, ISSN 0735-7907, E-ISSN 1532-4192, Vol. 37, no 2, p. 99-112Article in journal (Refereed) Published
Abstract [en]

Platelet-derived growth factor D (PDGF-D) has been shown to mediate cellular processes of importance in cancer progression. This study aimed to investigate the expression and putative involvement of PDGF-D signaling in colorectal carcinogenesis. PDGF-D was expressed in vascular endothelial cells in tumor and normal tissues. PDGF-D stimulation of cells altered genes of importance in carcinogenic processes. In addition, PDGF-D increased the proliferation rate while imatinib inhibited these effects. PDGF-D and its PDGF receptor beta (PDGFR-beta) are expressed in colorectal cancer and blockage of PDGF-D/PDGFR-beta signaling using tyrosine kinase inhibitors, such as imatinib, might be important in inhibiting tumor-promoting actions.

Place, publisher, year, edition, pages
TAYLOR & FRANCIS INC , 2019. Vol. 37, no 2, p. 99-112
Keywords [en]
Angiogenesis; Colorectal cancer; Imatinib; PDGF-D; Proliferation
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:liu:diva-156212DOI: 10.1080/07357907.2019.1576191ISI: 000462343500005PubMedID: 30836770OAI: oai:DiVA.org:liu-156212DiVA, id: diva2:1303218
Note

Funding Agencies|Foundation of Clinical Cancer Research, Jonkoping, Sweden [110426-1]; Futurum - the Academy for Health and Care, County Council of Jonkoping, Sweden [FUTURUM-105891]; FORSS, the Research Council of South-Eastern Sweden, Sweden [FORSS-373251]

Available from: 2019-04-09 Created: 2019-04-09 Last updated: 2019-04-09

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