Possible Role and Therapeutic Target of PDGF-D Signalling in Colorectal Cancer
2019 (English)In: Cancer Investigation, ISSN 0735-7907, E-ISSN 1532-4192, Vol. 37, no 2, p. 99-112Article in journal (Refereed) Published
Abstract [en]
Platelet-derived growth factor D (PDGF-D) has been shown to mediate cellular processes of importance in cancer progression. This study aimed to investigate the expression and putative involvement of PDGF-D signaling in colorectal carcinogenesis. PDGF-D was expressed in vascular endothelial cells in tumor and normal tissues. PDGF-D stimulation of cells altered genes of importance in carcinogenic processes. In addition, PDGF-D increased the proliferation rate while imatinib inhibited these effects. PDGF-D and its PDGF receptor beta (PDGFR-beta) are expressed in colorectal cancer and blockage of PDGF-D/PDGFR-beta signaling using tyrosine kinase inhibitors, such as imatinib, might be important in inhibiting tumor-promoting actions.
Place, publisher, year, edition, pages
TAYLOR & FRANCIS INC , 2019. Vol. 37, no 2, p. 99-112
Keywords [en]
Angiogenesis; Colorectal cancer; Imatinib; PDGF-D; Proliferation
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:liu:diva-156212DOI: 10.1080/07357907.2019.1576191ISI: 000462343500005PubMedID: 30836770OAI: oai:DiVA.org:liu-156212DiVA, id: diva2:1303218
Note
Funding Agencies|Foundation of Clinical Cancer Research, Jonkoping, Sweden [110426-1]; Futurum - the Academy for Health and Care, County Council of Jonkoping, Sweden [FUTURUM-105891]; FORSS, the Research Council of South-Eastern Sweden, Sweden [FORSS-373251]
2019-04-092019-04-092019-04-09