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Phenotyping of Lewis and secretor HBGA from saliva and detection of new FUT2 gene SNPs from young children from the Amazon presenting acute gastroenteritis and respiratory infection
Oswaldo Cruz Fdn FIOCRUZ, Brazil.
Univ Fed Roraima, Brazil; Oswaldo Cruz Fdn FIOCRUZ, Brazil.
Oswaldo Cruz Fdn FIOCRUZ, Brazil.
Oswaldo Cruz Fdn FIOCRUZ, Brazil.
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2019 (English)In: Infection, Genetics and Evolution, ISSN 1567-1348, E-ISSN 1567-7257, Vol. 70, p. 61-66Article in journal (Refereed) Published
Abstract [en]

The Histo-blood group antigens (HBGA) are host genetic factors associated with susceptibility to rotavirus (RV) and human norovirus (HuNoV), the major etiological agents of viral acute gastroenteritis (AGE) worldwide. The FUT2 gene expressing the alpha-1, 2-L- fucosyltransferase enzyme is important for gut HBGA expression, and also provides a composition of the phenotypic profile achieved through mutations occurring in populations with different evolutionary histories; as such, it can be considered a genetic population marker. In this study, Lewis and secretor HBGA phenotyping was performed using 352 saliva samples collected from children between three months and five years old born in the Amazon (Brazil, Venezuela and English Guyana) presenting AGE or acute respiratory infection (ARI), the latter considered as control samples. The total of children phenotyped as secretors was 323, corresponding to 91.80%. From these, 207 (58.80%) had a Le (a + b +) profile. The HBGA profiles were equally found in children with AGE as well as with ARI. The rs1047781 of the FUT2 gene was not detected in DNA from saliva cells with a Le (a + b +) profile. However, mutations not yet described in the FUT2 gene were observed: missense 325A amp;gt; T, 501C amp;gt; T, 585C amp;gt; T, 855A amp;gt; T and missense substitutions 327C amp;gt; T [S (Ser) amp;gt; C (Cys)], 446 T amp;gt; C [L(Leu) amp;gt; P(Pro)], 723C amp;gt; A [N(Asn) amp;gt; K(Lys)], 724A amp;gt; T [I(Ile) amp;gt; F(Phe)], 736C amp;gt; A [H(His) amp;gt; N(Asn)]. The SNP distribution in the FUT2 gene of the analyzed samples was very similar to that described in Asian populations, including indigenous tribes.

Place, publisher, year, edition, pages
ELSEVIER SCIENCE BV , 2019. Vol. 70, p. 61-66
Keywords [en]
Histo-blood group antigens; Saliva, weak secretor; Single nucleotide polymorphisms; Amazon
National Category
Infectious Medicine
Identifiers
URN: urn:nbn:se:liu:diva-156187DOI: 10.1016/j.meegid.2019.02.011ISI: 000462355300010PubMedID: 30790699OAI: oai:DiVA.org:liu-156187DiVA, id: diva2:1303307
Note

Funding Agencies|National Council for Scientific and Technological Development - CNPq; Carlos Chagas Filho Foundation for Research Support of the State of Rio de Janeiro -FAPERJ; Oswaldo Cruz Institute- IOC (PAEF)

Available from: 2019-04-09 Created: 2019-04-09 Last updated: 2019-04-09

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