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A branching gene regulatory network dictating different aspects of a neuronal cell identity
Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Medicine and Health Sciences. Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
Linköping University, Department of Clinical and Experimental Medicine, Division of Hematopoiesis and Developmental Biology. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Division of Hematopoiesis and Developmental Biology. Linköping University, Faculty of Medicine and Health Sciences. School of Biomedical Sciences, University of Queensland, Australia.ORCID iD: 0000-0001-5095-541X
2019 (English)In: Development, ISSN 0950-1991, E-ISSN 1477-9129, Vol. 146, no 6, article id UNSP 174300Article in journal (Refereed) Published
Abstract [en]

The nervous system displays a daunting cellular diversity. Neuronal subtypes differ from each other in several aspects, including their neurotransmitter expression and axon projection. These aspects can converge, but can also diverge, such that neurons expressing the same neurotransmitter may project axons to different targets. It is not well understood how regulatory programs converge/ diverge to associate/dissociate different cell fate features. Studies of the Drosophila Tv1 neurons have identified a regulatory cascade, ladybird early -amp;gt; collier -amp;gt; apterous/eyes absent -amp;gt; dimmed, that specifies Tv1 neurotransmitter expression. Here, we conduct genetic and transcriptome analysis to address how other aspects of Tv1 cell fate are governed. We find that an initiator terminal selector gene triggers a feedforward loop that branches into different subroutines, each of which establishes different features of this one unique neuronal cell fate.

Place, publisher, year, edition, pages
Cambridge, United Kingdom: The Company of Biologists Ltd. , 2019. Vol. 146, no 6, article id UNSP 174300
Keywords [en]
Cell fate specification; Terminal selector; Axon pathfinding; Genetic cascades; Feedforward loops
National Category
Developmental Biology
Identifiers
URN: urn:nbn:se:liu:diva-156398DOI: 10.1242/dev.174300ISI: 000462859300013PubMedID: 30837222Scopus ID: 2-s2.0-85063005708OAI: oai:DiVA.org:liu-156398DiVA, id: diva2:1305711
Note

Funding Agencies|Vetenskapsradet [621-2013-5258, 2017-0440601]; Knut och Alice Wallenbergs Stiftelse [KAW2011.0165, KAW2012.0101, KAW2017.0312]; Cancerfonden [140780, 150663, CAN2017/257]

Available from: 2019-04-18 Created: 2019-04-18 Last updated: 2019-04-24Bibliographically approved

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Ekman, Helen

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