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Proof of Concept for an Adaptive Treatment Strategy to Prevent Failures in Internet-Delivered CBT: A Single-Blind Randomized Clinical Trial With Insomnia Patients
Karolinska Inst, Sweden; Huddinge Hosp, Sweden.
Karolinska Inst, Sweden; Huddinge Hosp, Sweden; Karolinska Inst, Sweden.
Karolinska Inst, Sweden; Huddinge Hosp, Sweden.
Karolinska Inst, Sweden; Huddinge Hosp, Sweden.
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2019 (English)In: American Journal of Psychiatry, ISSN 0002-953X, E-ISSN 1535-7228, Vol. 176, no 4, p. 315-323Article in journal (Refereed) Published
Abstract [en]

Objective: This study aimed to demonstrate proof of concept for an adaptive treatment strategy in Internet-delivered cognitive-behavioral therapy (ICBT), where risk of treatment failure is assessed early in treatment and treatment for at-risk patients is adapted to prevent treatment failure. Methods: A semiautomated algorithm assessed risk of treatment failure early in treatment in 251 patients undergoing ICBT for insomnia with therapist guidance. At-risk patients were randomly assigned to continue standard ICBT or to receive adapted ICBT. The primary outcome was self-rated insomnia symptoms using the Insomnia Severity Index in a linear mixed-effects model. The main secondary outcome was treatment failure (having neither responded nor remitted at the posttreatment assessment). Results: A total of 102 patients were classified as at risk and randomly assigned to receive adapted ICBT (N=51) or standard ICBT (N=51); 149 patients were classified as not at risk. Patients not at risk had significantly greater score reductions on the Insomnia Severity Index than at-risk patients given standard ICBT. Adapted ICBT for at-risk patients was significantly more successful in reducing symptoms compared with standard ICBT, and it decreased the risk of failing treatment (odds ratio= 0.33). At-risk patients receiving adapted ICBT were not more likely to experience treatment failure than those not at risk (odds ratio= 0.51), though they were less likely to experience remission. Adapted treatment required, on average, 14 more minutes of therapist-patient time per remaining week. Conclusions: An adaptive treatment strategy can increase treatment effects for at-risk patients and reduce the number of failed treatments. Future studies should improve accuracy in classification algorithms and identify key factors that boost the effect of adapted treatments.

Place, publisher, year, edition, pages
AMER PSYCHIATRIC PUBLISHING, INC , 2019. Vol. 176, no 4, p. 315-323
National Category
Psychiatry
Identifiers
URN: urn:nbn:se:liu:diva-156381DOI: 10.1176/appi.ajp.2018.18060699ISI: 000462848100011PubMedID: 30696270OAI: oai:DiVA.org:liu-156381DiVA, id: diva2:1305813
Note

Funding Agencies|Soderstrom Konigska Foundation; L.J. Boethius Foundation; Brother Gadelius Foundation; Stockholm County Council; Erling-Persson Family Foundation; Swedish Research Council

Available from: 2019-04-18 Created: 2019-04-18 Last updated: 2019-04-18

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