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Evaluating Dissemination Mechanisms of Antibiotic-Resistant Bacteria in Rural Environments in China by Using CTX-M-Producing Escherichia coli as an Indicator
Shandong Univ, Peoples R China.
Zhejiang Univ, Peoples R China.
Ctr Dis Prevent and Control, Peoples R China.
Natl Food Agcy, Sweden.
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2019 (English)In: Microbial Drug Resistance, ISSN 1076-6294, E-ISSN 1931-8448Article in journal (Refereed) Epub ahead of print
Abstract [en]

It is becoming increasingly recognized that the environment plays an important role both in the emergence and in dissemination of antibiotic-resistant bacteria (ARB), Mechanisms and factors facilitating this development are, however, not yet well understood. The high detection rate of CTX-M genes in environmental sources provides an opportunity to explore this issue. In this study, 88 CTX-M-producing Escherichia coli were isolated from 30 pig feces samples from 30 pig farms and 201 environmental samples. CTX-M-producing E. coli was detected with the following frequencies in the different types of samples: pig feces, 73%; river water, 64%; river sediment, 52%; wastewater, 31%; drinking water, 23%; outlet sediment, 21%; soil, 17%; and vegetables, 4.4%. Dissemination of CTX-M-producing E. coli to different environmental matrices was evaluated by analyzing the genetic relatedness of isolates from different environmental sources, and putative transmission routes through bird feces, pig feces, drinking water, river sediment, river water, and wastewater were hypothesized. Dissemination through these routes is likely facilitated by anthropogenic activities and environmental factors. Wild birds as potential vectors for dissemination of CTX-M-producing E. coli have the capacity to spread ARB across long distances. Regional dissemination between different environmental matrices of CTX-M-producing E. coli increases the exposure risk of humans and animals in the area.

Place, publisher, year, edition, pages
Mary Ann Liebert, Inc., publishers , 2019.
Keywords [en]
ESBL-producing E; coli; dissemination mechanism; multiple environmental matrices; animal
National Category
Microbiology
Identifiers
URN: urn:nbn:se:liu:diva-156562DOI: 10.1089/mdr.2018.0431ISI: 000463256200001PubMedID: 30942653OAI: oai:DiVA.org:liu-156562DiVA, id: diva2:1315463
Note

Funding Agencies|National Natural Science Foundation of China [41771499, 81361138021]; Fundamental Research Funds of Shandong University [2018JC102]; Swedish Research Council; Public Health Agency of Sweden [D0879801]; Swedish Research Council Formas [2016-00640]

Available from: 2019-05-14 Created: 2019-05-14 Last updated: 2019-08-12Bibliographically approved

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The full text will be freely available from 2020-05-22 08:00
Available from 2020-05-22 08:00

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Nilsson, Lennart

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Division of Microbiology, Infection and InflammationFaculty of Medicine and Health Sciences
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