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Continuous-flow LVADs in the Nordic countries: complications and mortality and its predictors
Lund Univ, Sweden; Skane Univ Hosp, Sweden.
Skane Univ Hosp, Sweden; Lund Univ, Sweden.
Rigshosp, Denmark.
Sahlgrens Univ Hosp, Sweden.
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2019 (English)In: Scandinavian Cardiovascular Journal, ISSN 1401-7431, E-ISSN 1651-2006, Vol. 53, no 1, p. 14-20Article in journal (Refereed) Published
Abstract [en]

Objectives: The purpose of this study was to assess complications and mortality and its predictors, with continuous-flow left ventricular assist devices (CF-LVADs) in the Nordic Countries. Design: This was a retrospective, international, multicenter cohort study. Results: Between 1993 and 2013, 442 surgically implanted long-term mechanical assist devices were used among 8 centers in the Nordic countries. Of those, 238 were CF-LVADs (HVAD or HeartMate II) implanted in patients amp;gt;18 years with complete data. Postoperative complications and survival were compared and Cox proportion hazard regression analysis was used to identify predictors of mortality. The overall Kaplan-Meier survival rate was 75% at 1 year, 69% at 2 years and 63% at 3 years. A planned strategy of destination therapy had poorer survival compared to a strategy of bridge to transplantation or decision (2-year survival of 41% vs. 76%, p amp;lt; .001). The most common complications were non-driveline infections (excluding sepsis) (44%), driveline infection (27%), need for continuous renal replacement therapy (25%) and right heart failure (24%). In a multivariate model age and left ventricular diastolic dimension was left as independent risk factors for mortality with a hazard ratio of 1.35 (95% confidence interval (CI) [1.01-1.80], p = .046) per 10 years and 0.88 (95% CI [0.72-0.99], p = .044) per 5 mm, respectively. Conclusion: Outcome with CF LVAD in the Nordic countries was comparable to other cohorts. Higher age and destination therapy require particularly stringent selection.

Place, publisher, year, edition, pages
TAYLOR & FRANCIS LTD , 2019. Vol. 53, no 1, p. 14-20
Keywords [en]
Heart failure; mechanical circulatory support; left ventricular assist device; outcomes
National Category
Cardiology and Cardiovascular Disease
Identifiers
URN: urn:nbn:se:liu:diva-156588DOI: 10.1080/14017431.2019.1583365ISI: 000463610600002PubMedID: 30776923OAI: oai:DiVA.org:liu-156588DiVA, id: diva2:1315627
Note

Funding Agencies|Swedish Heart-Lung Foundation; Crafoords Foundation; Marta Winklers Stiftelse; Thorsten Westerstroms Stiftelse; ALF grants Region Skane; Anna-Lisa Lundbergs stiftelse; ALF grants Region Stockholm

Available from: 2019-05-14 Created: 2019-05-14 Last updated: 2025-02-10

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Hübbert, Laila
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Division of Cardiovascular MedicineFaculty of Medicine and Health SciencesDepartment of Cardiology in Norrköping
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