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Adding nanotechnology to the metastasis treatment arsenal.
Columbia University Medical Center, USA.
University of Oslo, Norway.
University of Cambridge, UK.
Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences.
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2019 (English)In: TIPS - Trends in Pharmacological Sciences, ISSN 0165-6147, E-ISSN 1873-3735, Vol. 40, no 6, p. 403-418Article, review/survey (Refereed) Published
Abstract [en]

Metastasis is a major cause of cancer-related mortality, accounting for 90% of cancer deaths. The explosive growth of cancer biology research has revealed new mechanistic network information and pathways that promote metastasis. Consequently, a large number of antitumor agents have been developed and tested for their antimetastatic efficacy. Despite their exciting cytotoxic effects on tumor cells in vitro and antitumor activities in preclinical studies in vivo, only a few have shown potent antimetastatic activities in clinical trials. In this review, we provide a brief overview of current antimetastatic strategies that show clinical efficacy and review nanotechnology-based approaches that are currently being incorporated into these therapies to mitigate challenges associated with treating cancer metastasis.

Place, publisher, year, edition, pages
Cambridge, Massachusets, 2019. Vol. 40, no 6, p. 403-418
Keywords [en]
metastasis; nanotechnology; chemotherapy; combination therapy
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-156845DOI: 10.1016/j.tips.2019.04.002ISI: 000469437500007PubMedID: 31076247OAI: oai:DiVA.org:liu-156845DiVA, id: diva2:1315714
Note

Funding agencies: EU H2020 Marie Sklodowska-Curie Individual Fellowship [706694]; Wolfson College (University of Cambridge, UK); MIIC Seed Grant from Linkoping University (LiU), Sweden

Available from: 2019-05-14 Created: 2019-05-14 Last updated: 2019-06-24

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Wiechec, EmiliaPatra, Hirak

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CiteExportLink to record
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Citation style
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