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Survival benefit of statins in older patients with rectal cancer: A Swedish population-based cohort study
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Department of Radiology in Linköping. Linköping University, Department of Medical and Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Oncology. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Oncology. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Oncology.
2019 (English)In: Journal of Geriatric Oncology, ISSN 1879-4068, E-ISSN 1879-4076Article in journal (Refereed) In press
Abstract [en]

Objectives

Increasing evidence suggests that statins may have antitumor effects but their rolein rectal cancer appears inconclusive. The aim of this study was to investigate whether statins may have an impact on survival of older and younger patients with rectal cancer.

Materials and Methods

This study included 238 patients ≥70 years and 227 patients <70 years old, from the Southeast Health Care Region of Sweden, who were diagnosed with rectal adenocarcinoma between 2004 and 2013.

Results

In the older group (n = 238), statin use at the time of diagnosis was related to better cancer-specific survival (CSS) and overall survival (OS), compared to non-use (CSS: Hazard Ratio (HR), 0.37; 95% CI, 0.19–0.72; P = .003; OS: HR, 0.62; 95% CI, 0.39–0.96; P = .032). In the older group with stages I-III disease (n = 199), statin use was associated with better disease-free survival (DFS) compared to non use (HR, 0.18; 95% CI, 0.06–0.59; P = .005). The improvement of CSS, OS and DFS remained significant after adjusting for potential confounders. In the older group with stage III disease, statin users had better CSS and DFS compared to non-users (log rank P = .043; log-rank P = .028, respectively). In the older group with short course radiotherapy, statin use was related to better CSS (log-rank P = .032). No such association was present in the younger group.

Conclusion

Statin use was related to improved survival in older patients with rectal cancer.

This observation is important given the low cost and safety of statins as a drug.

Place, publisher, year, edition, pages
Elsevier, 2019.
Keywords [en]
Statin;Rectal cancer;Survival;Older;Younger;Age;Stage;Radiotherapy;Outcome
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:liu:diva-157046DOI: 10.1016/j.jgo.2019.01.011PubMedID: 30692020Scopus ID: 2-s2.0-85060538794OAI: oai:DiVA.org:liu-157046DiVA, id: diva2:1317815
Available from: 2019-05-24 Created: 2019-05-24 Last updated: 2019-06-13Bibliographically approved

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Holmqvist, Annica

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Holmqvist, AnnicaAlbertsson, MariaSun, Xiao-Feng
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Division of Clinical SciencesFaculty of Medicine and Health SciencesDepartment of Radiology in LinköpingDepartment of Medical and Health SciencesDivision of Surgery, Orthopedics and OncologyDepartment of Oncology
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Journal of Geriatric Oncology
Cancer and Oncology

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