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The microvascular response in the skin to topical application of methyl nicotinate: Effect of concentration and variation between skin sites
Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences.ORCID iD: 0000-0002-6804-7708
Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Medical and Health Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Medical radiation physics.
Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Hand and Plastic Surgery.
2019 (English)In: Microvascular Research, ISSN 0026-2862, E-ISSN 1095-9319, Vol. 124, p. 54-60Article in journal (Refereed) Published
Abstract [en]

Background

Methyl nicotinate (MN) induces a local cutaneous erythema in the skin and may be used as a local provocation in the assessment of microcirculation and skin viability. The aims were to measure the effects of increasing doses of MN, to find the concentration that yields the most reproducible effect from day to day and between sites, and to study the variation between skin sites.

Methods

Microvascular responses to topically applied MN at different concentrations were measured in 12 subjects on separate days and on contralateral sides, using laserspeckle contrast imaging (LSCI). MN effects were measured in four different body sites.

Results

At 20 mmol/L, the response to MN was most reproducible day-to-day and site-to-site, and resulted in a plateau response between 5 and 20 min after application.

The skin region of the lower back had a lower perfusion value compared to the epigastric region (p = 0.007). When responses were compared to nearby, unprovoked areas, a significantly larger increase in perfusion was seen in the forearm, compared to all other anatomical sites (p < 0.03).

Conclusion

A concentration of 20 mmol/L MN generated the most reproducible microvascular response in the skin. The response varies between different body sites.

Place, publisher, year, edition, pages
Academic Press, 2019. Vol. 124, p. 54-60
National Category
Medical Laboratory and Measurements Technologies
Identifiers
URN: urn:nbn:se:liu:diva-156888DOI: 10.1016/j.mvr.2019.03.002ISI: 000466057200009PubMedID: 30877017Scopus ID: 2-s2.0-85062903925OAI: oai:DiVA.org:liu-156888DiVA, id: diva2:1318837
Available from: 2019-05-28 Created: 2019-05-28 Last updated: 2019-06-04Bibliographically approved

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Elawa, SherifMirdell, RobinTesselaar, ErikFarnebo, Simon
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Division of Surgery, Orthopedics and OncologyFaculty of Medicine and Health SciencesDepartment of Medical and Health SciencesMedical radiation physicsDepartment of Hand and Plastic Surgery
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Microvascular Research
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