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Inherited Ataxia and Intrathecal Baclofen for the Treatment of Spasticity and Painful Spasms
Uppsala Univ, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Local Health Care Services in Central Östergötland, Department of Neurology.
Uppsala Univ, Sweden.
Uppsala Univ, Sweden.
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2019 (English)In: Stereotactic and Functional Neurosurgery, ISSN 1011-6125, E-ISSN 1423-0372, Vol. 97, no 1, p. 18-23Article in journal (Refereed) Published
Abstract [en]

Background: Intrathecal baclofen (ITB) treatment is considered a powerful tool in the management of severe spasticity in neurological conditions such as multiple sclerosis, cerebral palsy, and traumatic spinal cord and brain injury. 

Objectives: The objective of this study was to assess the effectiveness of the ITB in patients with inherited ataxia suffering from severe painful spasms and/or spasticity. 

Method: A total of 5 patients with spinocerebellar ataxia 3 or 7 or Friedreich’s ataxia were included in this observational multicenter study. The patients were interviewed and completed outcome measures assessing pain (The Brief Pain Inventory), fatigue (Fatigue Severity Scale), and life satisfaction (LiSAT-9) before and 1 year after the treatment. Spasticity (Modified Ashworth Scale) and spasm frequency (SPFS) were measured objectively for each patient. 

Results: The mean treatment time was 1.9 years. Evaluation of established standard forms revealed symptomatic relief from spasticity, spasms, pain, and fatigue in addition to improved body posture, sleep, and life satisfaction after ITB treatment. 

Conclusions: We report the potential beneficial effects of ITB treatment in patients with inherited ataxia who also suffer from spasticity/spasms. ITB treatment indication in neurological disorders allows for extension to the treatment of spasticity/ spasms in patients with hereditary ataxia.

Place, publisher, year, edition, pages
S. Karger, 2019. Vol. 97, no 1, p. 18-23
Keywords [en]
Intrathecal baclofen treatment; Inherited ataxia; Spasms; Spasticity; Pain
National Category
Neurology
Identifiers
URN: urn:nbn:se:liu:diva-157571DOI: 10.1159/000497165ISI: 000467683300003PubMedID: 30870851Scopus ID: 2-s2.0-85063459883OAI: oai:DiVA.org:liu-157571DiVA, id: diva2:1328641
Available from: 2019-06-22 Created: 2019-06-22 Last updated: 2019-06-24Bibliographically approved

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Gauffin, HelenaLandtblom, Anne-Marie

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Division of Neuro and Inflammation ScienceFaculty of Medicine and Health SciencesDepartment of Neurology
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Stereotactic and Functional Neurosurgery
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