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Modulation of the inflammatory response after sclerotherapy for hydrocoele/spermatocoele
Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Urology in Östergötland.
Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Business support and Development, Regional Cancer Center.
Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Science & Engineering. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Urology in Östergötland.
2019 (English)In: BJU International, ISSN 1464-4096, E-ISSN 1464-410X, Vol. 123, no 5A, p. E63-E68Article in journal (Refereed) Published
Abstract [en]

Objective

To investigate the modulation of the inflammatory response after sclerotherapy for hydrocoele/spermatocoele.

Patients and Methods

All patients with hydrocoele or spermatocoele presenting at the Department of Urology, University Hospital, Linköping, Sweden, from 2006 to 2012, were included in this prospective observational study of sclerotherapy for hydrocoele/spermatocoele using polidocanol as a sclerosing agent and adjuvant antibiotic and anti‐inflammatory medication (AAAM) for modulation of the inflammatory response. Patients were clinically evaluated within 24–48 h after a complication or adverse event possibly related to sclerotherapy. Evaluation of cure was scheduled after 3 months and re‐treatment, if necessary was carried out in the same manner as the first treatment. Groups of patients were compared using the chi‐squared test and logistic regression analysis.

Results

From a total of 191 patients, AAAM was given to 126, of whom 5% had subclinical epididymitis/swelling (SES) compared to 26% of the patients without AAAM (P < 0.001). No other complication was observed. The rate of cure for the whole group of patients was 93% after one or two treatments and significantly higher in the group with AAAM than in the group without AAAM (96% vs 88%, P = 0.03).

Conclusions

Modulation of the inflammatory response after sclerotherapy resulted in a lower incidence of SES and an increased cure rate.

Place, publisher, year, edition, pages
Wiley-Blackwell Publishing Inc., 2019. Vol. 123, no 5A, p. E63-E68
Keywords [en]
sclerotherapy; hydrocoele; spermatocoele; polidocanol; inflammatory response
National Category
Surgery
Identifiers
URN: urn:nbn:se:liu:diva-157536DOI: 10.1111/bju.14562ISI: 000467445600009PubMedID: 30253006Scopus ID: 2-s2.0-85055250297OAI: oai:DiVA.org:liu-157536DiVA, id: diva2:1328679
Available from: 2019-06-22 Created: 2019-06-22 Last updated: 2019-06-26Bibliographically approved

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Rosell, Johan

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Jahnson, StaffanRosell, JohanAljabery, Firas
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Division of Surgery, Orthopedics and OncologyFaculty of Medicine and Health SciencesDepartment of Urology in ÖstergötlandDepartment of Clinical and Experimental MedicineRegional Cancer CenterFaculty of Science & Engineering
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BJU International
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