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Quality-adjusted life year weights among elderly patients with heart failure
Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Health Sciences, Cardiology . Östergötlands Läns Landsting, Heart Centre, Department of Cardiology.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Health Sciences, Health Technology Assessment and Health Economics.
AstraZeneca Sverige AB.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Health Sciences, Health Technology Assessment and Health Economics.
2008 (English)In: European journal of heart failure, ISSN 1388-9842, Vol. 10, no 10, 1033-1039 p.Article in journal (Refereed) Published
Abstract [en]

Background

When assessing health-related quality of life (HRQoL) in elderly patients with heart failure (HF), the process of obtaining quality-adjusted life year (QALY) weights is generally complicated and time-consuming.

Aim

To evaluate whether information regarding HRQoL and QALY weights can be derived directly from the established and widely used New York Heart Association (NYHA) functional classification system.

Methods

NYHA functional status was assessed independently both by the individual patients and by the examining cardiologist in 323 elderly patients with symptoms of HF recruited from primary care. HRQoL was evaluated using the SF-36 questionnaire and a time trade-off (TTO) scenario. The TTO technique generates direct QALY weights.

Results

Both the TTO technique and SF-36 values demonstrated a statistically significant correlation with NYHA functional status. The TTO values also correlated with all SF-36 dimensions. Increasing impairment was associated with statistically significant drops in both SF-36 values and TTO-based QALY weights. For patients in NYHA classes I–IV the QALY weights were 0.77, 0.68, 0.61, and 0.50, respectively. Thus in elderly patients, symptoms of HF have a major impact on perceived quality of life.

Conclusion

The results of the present study show that QALY weights, an important instrument in the health economic evaluation of treatment strategies, can be derived directly from NYHA classification in elderly HF patients.

Place, publisher, year, edition, pages
2008. Vol. 10, no 10, 1033-1039 p.
Keyword [en]
Heart failure, Elderly patients, Health related quality of life, QALY
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-16084DOI: 10.1016/j.ejheart.2008.07.015OAI: oai:DiVA.org:liu-16084DiVA: diva2:133108
Available from: 2009-01-07 Created: 2009-01-07 Last updated: 2009-08-17

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Alehagen, UrbanRahmqvist, MikaelLevin, Lars-Åke

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