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Synthesis and characterization of novel thiophene based tetramers for potential detection of protein aggregates
Linköping University, Department of Physics, Chemistry and Biology, Chemistry.
2019 (English)Independent thesis Advanced level (degree of Master (Two Years)), 40 credits / 60 HE creditsStudent thesis
Abstract [en]

Alzheimer’s disease is a big problem in the elderly population. An important tool in gaining insight in this disease are staining studies using different probes. Conjugated oligothiophenes have shown promising properties as probes and in this thesis new potential probes have been made.

Three new tetrameric probes have been synthesized, consisting of three thiophene units and one aromatic heterocycle moiety. The aromatic heterocycles used were BTD, pyridine and indole. The synthesis method involved Suzuki cross coupling, bromination with NBS and iridium catalyst borylation. The BTD and pyridine containing probes were tested in staining experiments and the pyridine probe showed promising results.

Place, publisher, year, edition, pages
2019. , p. 25
Keywords [en]
Organic chemistry, synthesis, oligothiophenes, Alzheimer’s Disease, Suzuki cross coupling, bromination
National Category
Organic Chemistry
Identifiers
URN: urn:nbn:se:liu:diva-157701ISRN: LITH-IFM-A-EX—19/3624--SEOAI: oai:DiVA.org:liu-157701DiVA, id: diva2:1331098
Subject / course
Chemistry
Presentation
2019-06-11, 09:45 (English)
Supervisors
Examiners
Available from: 2019-06-27 Created: 2019-06-26 Last updated: 2019-06-27Bibliographically approved

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CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf